{"id":"W2082326948","doi":"10.1371/journal.pmed.1000279","title":"Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies","year":2010,"lang":"en","type":"review","venue":"PLoS Medicine","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; McGill University; University of British Columbia","funders":"Cancer Council Victoria; National Cancer Institute; KWF Kankerbestrijding; Jewish General Hospital; National Institute for Health and Care Research; Canadian Breast Cancer Research Alliance; Breast Cancer Campaign; Helsingin ja Uudenmaan Sairaanhoitopiiri; NIHR Cambridge Biomedical Research Centre; Sanofi; Mayo Clinic; U.S. Department of Health and Human Services; National Institutes of Health; National Health and Medical Research Council; Cancer Research UK","keywords":"Breast cancer; Immunohistochemistry; Subtyping; Cytokeratin; Oncology; Internal medicine; Hormone receptor; Progesterone receptor; Cancer; Basal (medicine); Biology; Epidermal growth factor receptor; Pathology; Medicine; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04208965,0.001024509,0.004080501,0.02219097,0.001107561,0.002784396,0.002078172,0.0009489155,0.0009016529],"category_scores_gemma":[0.05626443,0.001001464,0.005958145,0.01556372,0.0006090312,0.001101603,0.002829987,0.0005478413,0.0002482639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009494106,"about_ca_system_score_gemma":0.001394377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005539731,"about_ca_topic_score_gemma":0.009275275,"domain_scores_codex":[0.9652308,0.01125365,0.01167338,0.00591349,0.005050191,0.0008784436],"domain_scores_gemma":[0.8758726,0.04425548,0.04507532,0.02061121,0.01232855,0.0018568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0003247324,0.00001128913,0.9809949,0.0005332426,0.0107543,0.0001368199,0.0003956296,0.0001395928,0.0005766918,0.00001917651,0.0001779299,0.005935729],"study_design_scores_gemma":[0.0000766828,0.0001865617,0.9818456,0.0004343467,0.01341716,0.0009724188,0.0005981307,0.0004818514,0.0004760551,0.00009768682,0.00137788,0.00003571203],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9363433,0.04520964,0.007857492,0.0001416615,0.0000625967,0.0006820388,0.008275554,0.00009614015,0.001331666],"genre_scores_gemma":[0.9862543,0.003170306,0.004824626,0.00005784192,0.00003411496,0.0005177453,0.004951599,0.0000489617,0.0001404833],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.04208965,"threshold_uncertainty_score":0.222594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1702420528565186,"score_gpt":0.4278137955772091,"score_spread":0.2575717427206904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}