{"id":"W2082339380","doi":"10.1038/480329a","title":"A drug-resistant duo","year":2011,"lang":"en","type":"letter","venue":"Nature","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Vemurafenib; Acquired resistance; Drug resistance; Cancer research; Melanoma; Drug; Medicine; Kinase; Mutant; Pharmacology; Metastatic melanoma; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005201842,0.0004876995,0.0004257466,0.0003395985,0.001379808,0.001425265,0.0004712198,0.00942664,0.004261165],"category_scores_gemma":[0.002189165,0.000234914,0.0007778273,0.0002038129,0.0008015663,0.001041404,0.0005872734,0.006645411,0.001893102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001240438,"about_ca_system_score_gemma":0.0004666761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057904,"about_ca_topic_score_gemma":0.001691115,"domain_scores_codex":[0.9997166,0.00005697086,0.00002718901,0.0000641054,0.00005858004,0.00007651988],"domain_scores_gemma":[0.9995831,0.0001579418,0.00003704532,0.00005003234,0.00004797066,0.0001238767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007911768,0.0002204354,0.003315611,0.0001835658,0.00007931625,0.1966941,0.0002750662,0.0002640529,0.01462717,0.03568199,0.6970751,0.05079242],"study_design_scores_gemma":[0.0003141715,0.0002718524,0.002912089,0.0001020721,0.00007513251,0.118252,0.0002822893,0.002071329,0.005078843,0.02038397,0.850206,0.00005021264],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03762839,0.00867808,0.002287559,0.8553898,0.03944993,0.0001551843,0.0006863613,0.0003204457,0.05540413],"genre_scores_gemma":[0.2926976,0.01002228,0.004538233,0.5508073,0.03235363,0.0001978207,0.0004749697,0.0001591022,0.108749],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.00942664,"threshold_uncertainty_score":0.01425505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006980386219293363,"score_gpt":0.2142752218983333,"score_spread":0.2072948356790399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}