{"id":"W2082343642","doi":"10.2147/ijn.s25741","title":"Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake","year":2011,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China; National Science and Technology Major Project; National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology; Novo Nordisk","keywords":"Liposome; Drug delivery; In vitro; Mucus; Drug; Drug carrier; Chemistry; Nanotechnology; Pharmacology; Materials science; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003372461,0.0004215789,0.0002867759,0.0002363753,0.0001291048,0.0002544624,0.0001971173,0.0005689171,0.0003301068],"category_scores_gemma":[0.0002994179,0.0001414143,0.0002135513,0.0001149382,0.0001955496,0.0005082909,0.0002160365,0.0002978077,0.0001476114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003075442,"about_ca_system_score_gemma":0.0001684274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003109435,"about_ca_topic_score_gemma":0.0003838461,"domain_scores_codex":[0.9998891,0.00002799946,0.00001202649,0.00002033836,0.00003164484,0.0000188845],"domain_scores_gemma":[0.9998741,0.00002857369,0.0000426956,0.00000850891,0.00002802947,0.00001814291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004667195,0.00001227635,0.0001041295,0.00006711973,0.00000349308,0.0000326813,0.000009679783,0.00006125932,0.998383,0.00002830217,0.00000931487,0.001242076],"study_design_scores_gemma":[0.00002406852,0.0004212996,0.000923506,0.000008663411,0.00002624007,0.0003134948,0.00001229048,0.0007390215,0.995931,0.00001682255,0.001575489,0.000008101877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827548,0.005812678,0.01057157,0.0001806051,0.00002362794,0.0001141509,0.0001169316,0.00004266777,0.0003829168],"genre_scores_gemma":[0.9781972,0.002651564,0.01769721,0.00007143972,0.00001696324,0.0000795883,0.0002899911,0.00001723711,0.0009788283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005689171,"threshold_uncertainty_score":0.002231419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04421381458073229,"score_gpt":0.3534871675728256,"score_spread":0.3092733529920932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}