{"id":"W2082366973","doi":"10.1126/science.1248229","title":"A Promiscuous Intermediate Underlies the Evolution of LEAFY DNA Binding Specificity","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of Alberta","funders":"Natural Environment Research Council; Sight Research UK","keywords":"Leafy; Gene duplication; Biology; Gene; Genetics; Genome; DNA; Transcription factor; Function (biology); Plant evolution; Computational biology; Evolutionary biology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001274901,0.00005465138,0.00007523866,0.00002004713,0.0002976223,0.00004036051,0.0006852632,0.0000325847,0.00003175257],"category_scores_gemma":[0.0003709207,0.00001532294,0.00003078378,0.0005931603,0.001136056,0.0000744163,0.0001758635,0.00009333172,0.00004349433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004648364,"about_ca_system_score_gemma":0.00002934004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006841874,"about_ca_topic_score_gemma":0.0002409995,"domain_scores_codex":[0.9990326,0.00009640049,0.0001007723,0.0002168764,0.0002899844,0.000263416],"domain_scores_gemma":[0.9996058,0.0001558484,0.00005642682,0.00007016461,0.00006377098,0.00004796081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000005944544,0.00001097479,0.00941701,0.000001298708,9.950096e-7,3.259354e-7,0.00003720494,9.207219e-7,0.98158,0.001051894,0.00002814852,0.007865245],"study_design_scores_gemma":[0.00007579648,0.0003571174,0.819155,0.00002367521,0.000003383703,0.0000177574,0.0007199416,0.0007639621,0.1735774,0.002924969,0.002251624,0.000129409],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975136,0.00002410531,0.00003410689,0.0007177735,0.00009033435,0.0001080141,0.000007429499,0.00001669379,0.001487926],"genre_scores_gemma":[0.9997305,0.000005652558,0.00002257626,0.00002461125,0.00005306669,0.00000378231,0.000002473085,2.10453e-7,0.0001570784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.809738,"threshold_uncertainty_score":0.4185848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02219357072534255,"score_gpt":0.2431933618533634,"score_spread":0.2209997911280209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}