{"id":"W2082366973","doi":"10.1126/science.1248229","title":"A Promiscuous Intermediate Underlies the Evolution of LEAFY DNA Binding Specificity","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of Alberta","funders":"Natural Environment Research Council; Sight Research UK","keywords":"Leafy; Gene duplication; Biology; Gene; Genetics; Genome; DNA; Transcription factor; Function (biology); Plant evolution; Computational biology; Evolutionary biology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148965,0.0001675864,0.0002175992,0.0002507762,0.0002958606,0.0005732179,0.000277789,0.0004781685,0.0006350859],"category_scores_gemma":[0.000301145,0.0001907803,0.000220659,0.0001524531,0.0005782053,0.0003492289,0.0005461596,0.0007766541,0.0002309863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003616783,"about_ca_system_score_gemma":0.0001869557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005060131,"about_ca_topic_score_gemma":0.0007559143,"domain_scores_codex":[0.999895,0.00001021638,0.000006806011,0.00004208138,0.00002176524,0.0000241234],"domain_scores_gemma":[0.9997881,0.00003374228,0.00007131873,0.00003808047,0.00001917307,0.00004958451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008532991,0.00001130148,0.005018146,0.00002425579,0.000006772781,0.0001983505,0.0001666884,0.0001670967,0.9900861,0.001184789,0.00001996974,0.003031241],"study_design_scores_gemma":[0.00005158954,0.0009127258,0.2919004,0.00005351474,0.0001055044,0.004802011,0.0007029726,0.008280677,0.6691763,0.006497492,0.01744146,0.00007532171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995933,0.0002858615,0.002825782,0.00005351887,0.000004389478,0.00000534817,0.00004502182,0.00005011787,0.0007970536],"genre_scores_gemma":[0.9980462,0.00009980164,0.001176362,0.0000364047,0.000004010423,0.000004846753,0.00007195844,0.00001364497,0.0005468228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006350859,"threshold_uncertainty_score":0.002624214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02219357072534255,"score_gpt":0.2431933618533634,"score_spread":0.2209997911280209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}