{"id":"W2082398159","doi":"10.1371/journal.pone.0026981","title":"Structural Basis for Broad Neutralization of Hepatitis C Virus Quasispecies","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis C virus research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Health Canada; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete; Elizabeth Glaser Pediatric AIDS Foundation","keywords":"Viral quasispecies; Alanine scanning; Hypervariable region; Virology; Biology; Epitope; Peptide sequence; Virus; Hepatitis C virus; Antibody; Neutralization; Mutagenesis; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371884,0.0002266355,0.0001907957,0.0001499076,0.0002055522,0.0002333077,0.0001752725,0.0002983985,0.0009809242],"category_scores_gemma":[0.0001613954,0.0001552519,0.0002519118,0.00005760615,0.0002004426,0.0001150864,0.0002521435,0.0003596329,0.0003222724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232281,"about_ca_system_score_gemma":0.0001421938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004531633,"about_ca_topic_score_gemma":0.0004376787,"domain_scores_codex":[0.9998888,0.00001878094,0.000007265292,0.00001741597,0.00003201779,0.00003564417],"domain_scores_gemma":[0.9998866,0.00002222723,0.00002932036,0.00001153835,0.00001700853,0.00003319108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001044959,0.0000324642,0.001480479,0.00002019739,0.00001218675,0.0001224893,0.00002127967,0.0003653972,0.9961095,0.0002516889,0.00002982341,0.001449945],"study_design_scores_gemma":[0.0001978416,0.002118543,0.1178786,0.00002848309,0.00009705419,0.004541018,0.0001485553,0.02012341,0.8467479,0.001978711,0.006107277,0.00003247097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957657,0.0004384754,0.002096191,0.00005944071,0.000008915651,0.0000179738,0.00004648735,0.00004747368,0.001519329],"genre_scores_gemma":[0.999324,0.00005882407,0.0003730322,0.00004656515,0.000003488531,0.000003745354,0.00005120916,0.000002603621,0.0001366465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009809242,"threshold_uncertainty_score":0.003281474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1787007279852681,"score_gpt":0.3114948070529831,"score_spread":0.132794079067715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}