{"id":"W2082415938","doi":"10.1021/bi4011489","title":"Structure of Signal Peptide Peptidase A with C-Termini Bound in the Active Sites: Insights into Specificity, Self-Processing, and Regulation","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Simon Fraser University; Canadian Light Source","keywords":"Peptide; Antiparallel (mathematics); Cleave; C-terminus; Bacillus subtilis; Signal peptide; N-terminus; Active site; Peptide sequence; Zymogen; Chemistry; Protein structure; Biochemistry; Signal peptidase; Amino acid; Biophysics; Enzyme; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002513657,0.0001729243,0.0001294908,0.00002282298,0.0000628787,0.00005018845,0.0001561572,0.0001913941,0.00003219126],"category_scores_gemma":[0.00001493588,0.0001126838,0.00002770093,0.0001193254,0.0001579535,0.00001615504,0.00005830108,0.00011353,6.225851e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001418589,"about_ca_system_score_gemma":0.00005345048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002297045,"about_ca_topic_score_gemma":0.00001542057,"domain_scores_codex":[0.9991904,0.00002628141,0.0001868823,0.0003125893,0.0001479374,0.0001358373],"domain_scores_gemma":[0.9994899,0.000009558507,0.0001391787,0.000202316,0.0001094058,0.00004963816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006797067,0.00002913913,0.002859884,0.0001112565,0.00001294935,0.000001024971,0.0004391524,0.000001103639,0.9953365,0.000005949504,0.0001066314,0.001028475],"study_design_scores_gemma":[0.0003159416,0.00009480101,0.04763326,0.00003790852,0.00001209834,0.00002529362,0.0003065203,0.0001202561,0.9508975,0.0002702051,0.0001235646,0.0001626878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992951,0.000204598,0.00003507275,0.00007982519,0.000007948775,0.0001730896,0.00001072804,0.000007632443,0.0001860311],"genre_scores_gemma":[0.998796,0.00001991556,0.0004987434,0.00008908358,0.0001506341,0.00001042185,0.0003523827,0.00001122704,0.00007160414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04477338,"threshold_uncertainty_score":0.4595113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00465580807128316,"score_gpt":0.2045445817104553,"score_spread":0.1998887736391721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}