{"id":"W2082415938","doi":"10.1021/bi4011489","title":"Structure of Signal Peptide Peptidase A with C-Termini Bound in the Active Sites: Insights into Specificity, Self-Processing, and Regulation","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Simon Fraser University; Canadian Light Source","keywords":"Peptide; Antiparallel (mathematics); Cleave; C-terminus; Bacillus subtilis; Signal peptide; N-terminus; Active site; Peptide sequence; Zymogen; Chemistry; Protein structure; Biochemistry; Signal peptidase; Amino acid; Biophysics; Enzyme; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007945496,0.0002275813,0.0002548278,0.0001362693,0.0002111978,0.0003792004,0.0003708183,0.000406664,0.0004928894],"category_scores_gemma":[0.0001545992,0.0001757044,0.0002315001,0.0001437296,0.000268263,0.0002495602,0.0001113534,0.0006070961,0.0003016698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005644726,"about_ca_system_score_gemma":0.0003262818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113739,"about_ca_topic_score_gemma":0.0008340389,"domain_scores_codex":[0.9999506,0.000007148283,0.000003310347,0.00001367299,0.00001768562,0.000007500043],"domain_scores_gemma":[0.9998564,0.00002583647,0.00004359097,0.000008528355,0.00001908998,0.00004650907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004600975,0.0001330103,0.003222435,0.0001108366,0.0000197251,0.0007923531,0.0001051387,0.004477925,0.9850351,0.001666805,0.0002319717,0.003744646],"study_design_scores_gemma":[0.0003286036,0.001575592,0.04566932,0.00008745384,0.00009010884,0.003581139,0.0003462031,0.1624447,0.7695984,0.004054686,0.01212295,0.0001009572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995066,0.00137921,0.002401977,0.0000919403,0.000009823617,0.00001215817,0.00008984426,0.00003660671,0.0009122895],"genre_scores_gemma":[0.9953222,0.0003871329,0.003334108,0.00004934452,0.000005486789,0.000009136153,0.0002916642,0.000008627067,0.0005923851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113739,"threshold_uncertainty_score":0.004095554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00465580807128316,"score_gpt":0.2045445817104553,"score_spread":0.1998887736391721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}