{"id":"W2082434850","doi":"10.2174/1875042701103010016","title":"Mapping the Binding and Calmodulin-Dependent Activation of Nitric Oxide Synthase Isozymes","year":2011,"lang":"en","type":"article","venue":"The Open Nitric Oxide Journal","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Calmodulin; Endothelial NOS; Nitric oxide synthase; Mutant; Gene isoform; Biochemistry; Nitric Oxide Synthase Type III; Isozyme; Nitric oxide; Cytosol; Chemistry; Enos; Enzyme; Cell biology; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135914,0.0002354595,0.0002573249,0.00011538,0.0001555908,0.0002426174,0.0004397368,0.0004242249,0.0005827817],"category_scores_gemma":[0.0003997302,0.0001727158,0.000230125,0.0001298769,0.0003014458,0.0002402289,0.0002141281,0.000660231,0.0002125912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821363,"about_ca_system_score_gemma":0.0001692775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008219058,"about_ca_topic_score_gemma":0.001125432,"domain_scores_codex":[0.9997908,0.00004140396,0.00001011213,0.00006389147,0.00005680214,0.00003690934],"domain_scores_gemma":[0.9998394,0.00006110081,0.00004201016,0.00001450437,0.00001915703,0.00002381258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000225369,0.000006106248,0.00007890915,0.0000177667,0.000001162691,0.00001519485,0.000008370898,0.00006311607,0.9992211,0.0000736289,0.000008668091,0.0004835424],"study_design_scores_gemma":[0.0000105307,0.00008128968,0.004637137,0.000007179029,0.000006557309,0.0001543365,0.00002575894,0.003535836,0.989565,0.0001202629,0.001848873,0.000007141186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675269,0.002210054,0.02786876,0.0001345863,0.00004340963,0.00006221719,0.0001851677,0.00005218977,0.001916811],"genre_scores_gemma":[0.9722213,0.001196409,0.02421873,0.0001219584,0.00001197417,0.00006922138,0.0003227185,0.00002896044,0.001808794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008219058,"threshold_uncertainty_score":0.002047062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07010373758004868,"score_gpt":0.2824791651238099,"score_spread":0.2123754275437612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}