{"id":"W2082473289","doi":"10.1016/j.cyto.2008.07.186","title":"144 Molecular mechanisms of MHC class II inhibition by the MARCH1 ubiquitin ligase in response to IL-10","year":2008,"lang":"en","type":"article","venue":"Cytokine","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Ubiquitin; MHC class II; Chemistry; Computational biology; Biology; Major histocompatibility complex; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005930222,0.0001674399,0.0002657632,0.000198279,0.0001530131,0.000004329793,0.0002160192,0.0001852753,0.0007247579],"category_scores_gemma":[0.0003514014,0.000130869,0.00009086607,0.000240374,0.0002121443,0.00004419863,0.000200367,0.0002644492,0.0003393529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000586929,"about_ca_system_score_gemma":0.00007498292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000644483,"about_ca_topic_score_gemma":0.00001184737,"domain_scores_codex":[0.998356,0.0006615027,0.0003632114,0.0002338438,0.00005489365,0.0003305448],"domain_scores_gemma":[0.9992512,0.0001954806,0.00008599555,0.0003689259,0.00007530029,0.0000230386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00664213,0.0001913665,0.000005159558,0.000005712514,0.00002841619,0.00004675501,0.0006325316,0.000004162231,0.9745521,0.0009052726,0.01658207,0.0004043093],"study_design_scores_gemma":[0.00124379,0.001170064,0.0005937355,0.00005554432,0.000008978066,0.0001882346,0.0002001607,0.000001949246,0.9242754,0.0001529244,0.07197833,0.0001309058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944023,0.0005716419,0.0005807698,0.003262406,0.0001494225,0.0002998387,0.0001264859,0.00003268184,0.0005744749],"genre_scores_gemma":[0.988299,0.0000343527,0.00004469159,0.001100583,0.000007165941,0.00004337458,0.00007152735,0.0000200308,0.01037924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05539627,"threshold_uncertainty_score":0.7935591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103108582146858,"score_gpt":0.2329452776269796,"score_spread":0.2226344194122938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}