{"id":"W2082481785","doi":"10.1007/s00005-011-0135-0","title":"Transitional B Cells: How Well Are the Checkpoints for Specificity Understood?","year":2011,"lang":"en","type":"review","venue":"Archivum Immunologiae et Therapiae Experimentalis","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Spleen; Bone marrow; Autoantibody; Biology; Immunology; Immune system; B cell; Transitional Cell; B-1 cell; Function (biology); Cell biology; Repertoire; Antibody; Antigen-presenting cell; T cell; Genetics; Transitional cell carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100155,0.001034115,0.002314185,0.001562833,0.0003696606,0.001657785,0.001887645,0.002486113,0.002033222],"category_scores_gemma":[0.0009985636,0.0003796215,0.0003730735,0.001420557,0.001293437,0.003627355,0.0008199067,0.003455625,0.003108287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001027944,"about_ca_system_score_gemma":0.00156623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001739085,"about_ca_topic_score_gemma":0.001509911,"domain_scores_codex":[0.9997345,0.00005182829,0.00003547306,0.00005272879,0.00008361278,0.00004184234],"domain_scores_gemma":[0.9995583,0.0001688497,0.00006722014,0.00002018757,0.0001215128,0.00006393999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000148768,0.0000334193,0.0002269046,0.01348156,0.00006010056,0.0002757222,0.0001258701,0.0002965991,0.002903351,0.008727926,0.02452797,0.9491918],"study_design_scores_gemma":[0.00002346192,0.00009438441,0.0006956598,0.002760783,0.0000537208,0.001577699,0.0001267052,0.000072692,0.0007709661,0.005415314,0.988386,0.00002276379],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007047061,0.9986689,0.0001238308,0.0004660986,0.0002245959,0.0000024091,0.000005391003,0.000004817904,0.0004334124],"genre_scores_gemma":[0.0006272823,0.9980895,0.0001526603,0.0003999544,0.0002538382,0.000005206071,0.00001642153,0.000001605204,0.000453446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002486113,"threshold_uncertainty_score":0.00745827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0718743363606356,"score_gpt":0.2981395537664307,"score_spread":0.2262652174057951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}