{"id":"W2082481785","doi":"10.1007/s00005-011-0135-0","title":"Transitional B Cells: How Well Are the Checkpoints for Specificity Understood?","year":2011,"lang":"en","type":"review","venue":"Archivum Immunologiae et Therapiae Experimentalis","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Spleen; Bone marrow; Autoantibody; Biology; Immunology; Immune system; B cell; Transitional Cell; B-1 cell; Function (biology); Cell biology; Repertoire; Antibody; Antigen-presenting cell; T cell; Genetics; Transitional cell carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.0007204729,0.001501991,0.00253986,0.0003660681,0.001026496,0.0001258392,0.002351622,0.001400638,0.002383728],"category_scores_gemma":[0.00003147324,0.00100189,0.002118141,0.0002827571,0.0022524,0.0002051534,0.000451258,0.001982626,0.001593014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593248,"about_ca_system_score_gemma":0.0003018001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142446,"about_ca_topic_score_gemma":0.0000312401,"domain_scores_codex":[0.9939266,0.002056938,0.00109429,0.001415433,0.0001111011,0.001395681],"domain_scores_gemma":[0.996078,0.001032326,0.00111753,0.001634876,0.00008334024,0.00005396545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00136746,0.002985998,0.000002914184,0.00221663,0.01157199,0.00003437745,0.005280985,5.150484e-7,0.6389372,0.01627378,0.04970879,0.2716193],"study_design_scores_gemma":[0.001815414,0.0005953863,0.000003123945,0.001071193,0.0005118433,0.000243401,0.002949272,1.901703e-7,0.06987341,0.0006154093,0.9212446,0.001076757],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001985657,0.9876898,0.0003871087,0.0007729862,0.003525244,0.002955954,0.001114183,0.0003185833,0.003037599],"genre_scores_gemma":[0.003925072,0.981713,0.0002520999,0.0005278693,0.0001709732,0.001632146,0.002705614,0.000241414,0.008831836],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8715358,"threshold_uncertainty_score":0.9998958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0718743363606356,"score_gpt":0.2981395537664307,"score_spread":0.2262652174057951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}