{"id":"W2082564115","doi":"10.1016/j.cmet.2013.10.001","title":"mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation","year":2013,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":838,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University","keywords":"mTORC1; EIF4E; Translation (biology); Mitochondrial biogenesis; Cell biology; Biology; Mitochondrion; PI3K/AKT/mTOR pathway; Eukaryotic initiation factor; Biogenesis; Mechanistic target of rapamycin; Translational regulation; Protein biosynthesis; Messenger RNA; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003199342,0.000619569,0.0003844837,0.0006544646,0.0005656017,0.0007797475,0.0003553744,0.0003263185,0.001965982],"category_scores_gemma":[0.0002971347,0.0003112739,0.0003481692,0.0004231663,0.0005023059,0.0004908938,0.0005078793,0.0006973263,0.0008086906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001249342,"about_ca_system_score_gemma":0.000542422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001706168,"about_ca_topic_score_gemma":0.003726526,"domain_scores_codex":[0.9997489,0.00004082321,0.00001995866,0.00006098904,0.00006195953,0.00006737096],"domain_scores_gemma":[0.9998456,0.00001433026,0.00004752684,0.00001614126,0.00004038554,0.0000358893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001074983,0.00008062692,0.0008422094,0.0001308556,0.00002988182,0.0001251738,0.00003780054,0.0004278267,0.9847465,0.002086403,0.001197589,0.009220141],"study_design_scores_gemma":[0.00008205007,0.0002138314,0.02782134,0.00002053673,0.00004695774,0.0002988249,0.00007831079,0.003654486,0.9528567,0.001259497,0.01364138,0.0000262179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9356143,0.02588588,0.01424306,0.003265591,0.0005843915,0.0001031655,0.003500629,0.001112143,0.01569069],"genre_scores_gemma":[0.9864413,0.002953683,0.002864841,0.0001912158,0.0000837054,0.00004865856,0.001297939,0.0001044891,0.006014138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965982,"threshold_uncertainty_score":0.009064674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009789306616241425,"score_gpt":0.2323446094650559,"score_spread":0.2225553028488144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}