{"id":"W2082573389","doi":"10.3899/jrheum.110235","title":"Polymorphisms in the Interleukin 4, Interleukin 13, and Corresponding Receptor Genes Are Not Associated with Systemic Sclerosis and Do Not Influence Gene Expression","year":2011,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Consejo Superior de Investigaciones Científicas; National Institutes of Health; Junta de Andalucía; Instituto de Salud Carlos III; Dutch Arthritis Association; Etablissement Français du Sang; Institut National de la Santé et de la Recherche Médicale; Burroughs Wellcome Fund; European League Against Rheumatism; Scleroderma Research Foundation","keywords":"Single-nucleotide polymorphism; Immunology; Interleukin 12 receptor, beta 1 subunit; Interleukin 4; Medicine; Interleukin-7 receptor; Interleukin 13; Gene; TaqMan; Genotype; Interleukin; Receptor; SNP; Interleukin-4 receptor; Interleukin 10; Immune system; Biology; Genetics; Real-time polymerase chain reaction; Internal medicine; Cytokine; T cell; IL-2 receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005398999,0.0003847976,0.0004837628,0.0004137578,0.0002039383,0.0002991679,0.0002711694,0.0004005036,0.00442855],"category_scores_gemma":[0.002300813,0.0001242912,0.0003706315,0.0005586418,0.0003706167,0.0001274957,0.0001454789,0.000282428,0.0005280096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515888,"about_ca_system_score_gemma":0.0001986776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007426604,"about_ca_topic_score_gemma":0.0007270001,"domain_scores_codex":[0.9993353,0.0001685831,0.00008125792,0.0002233697,0.0001302239,0.00006120068],"domain_scores_gemma":[0.9981946,0.0008076482,0.0005943312,0.0001620804,0.0001385574,0.0001027336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001739897,0.00006749773,0.9539227,0.00009027199,0.0004387411,0.001042707,0.0001393651,0.0003049055,0.03517549,0.00005625551,0.0001401992,0.00688188],"study_design_scores_gemma":[0.0001221999,0.0005509772,0.9889768,0.00003376167,0.0003598752,0.003309262,0.0000722679,0.0005942006,0.004842301,0.0001186034,0.001011906,0.000007899979],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985151,0.0003168689,0.0004841757,0.00002594783,0.0000072321,0.000008187528,0.0002956716,0.000007217245,0.0003396058],"genre_scores_gemma":[0.9991186,0.00005917588,0.0002773419,0.00002040877,0.00000844021,0.00001397367,0.0001992352,0.000005524956,0.0002972653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00442855,"threshold_uncertainty_score":0.01481491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03192650064136145,"score_gpt":0.2337606073783242,"score_spread":0.2018341067369628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}