{"id":"W2082582948","doi":"10.1002/pro.63","title":"Triad of polar residues implicated in pH specificity of acidic mammalian chitinase","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Studies on Chitinases and Chitosanases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"Lawrence Berkeley National Laboratory","keywords":"Chitinase; Catalytic triad; Active site; Biochemistry; Enzyme; Chemistry; Substrate (aquarium); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265607,0.0002423657,0.0002537296,0.0001081234,0.0001927958,0.0003117625,0.0001824965,0.0003281469,0.001577815],"category_scores_gemma":[0.000209981,0.0001551836,0.0002318453,0.0001009527,0.0003704383,0.0002970624,0.0002709386,0.00047918,0.0006077162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969282,"about_ca_system_score_gemma":0.0001537432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001659234,"about_ca_topic_score_gemma":0.0001711015,"domain_scores_codex":[0.9999273,0.00001805269,0.000006168294,0.00001726541,0.00001622583,0.00001496342],"domain_scores_gemma":[0.9998154,0.00003787314,0.0000468629,0.00001661828,0.00001753883,0.00006571854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004062478,0.00002311193,0.0006736494,0.00003926051,0.000009572283,0.0004044437,0.00004071622,0.0002220315,0.9961156,0.0002969645,0.00005513461,0.001713316],"study_design_scores_gemma":[0.0001351234,0.000654544,0.02490591,0.00002185458,0.0000568131,0.003613739,0.0001729702,0.00308416,0.9624951,0.0009949072,0.003825838,0.00003892835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992572,0.000877847,0.004501867,0.000166894,0.00002644223,0.00001617396,0.00006190645,0.00009365183,0.001683225],"genre_scores_gemma":[0.9978308,0.0001741549,0.001226777,0.00008121253,0.000007682331,0.000006214788,0.00008640315,0.00001399101,0.0005725774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001577815,"threshold_uncertainty_score":0.005278349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532879342387218,"score_gpt":0.2790850532357122,"score_spread":0.26375625981184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}