{"id":"W2082582948","doi":"10.1002/pro.63","title":"Triad of polar residues implicated in pH specificity of acidic mammalian chitinase","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Studies on Chitinases and Chitosanases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"Lawrence Berkeley National Laboratory","keywords":"Chitinase; Catalytic triad; Active site; Biochemistry; Enzyme; Chemistry; Substrate (aquarium); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436364,0.000107505,0.0001833253,0.00009087539,0.00006581879,0.000008442516,0.0003757168,0.00004723857,0.00001134894],"category_scores_gemma":[0.0002511603,0.00009479849,0.00005913032,0.0004949782,0.0005908137,0.000006250542,0.00007500982,0.00005788447,9.523177e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008732266,"about_ca_system_score_gemma":0.0001051185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001258246,"about_ca_topic_score_gemma":0.0001122171,"domain_scores_codex":[0.9988419,0.00003222066,0.0002978167,0.0003357279,0.0002318881,0.000260438],"domain_scores_gemma":[0.9993338,0.000006567391,0.0001556915,0.0003463686,0.00009679191,0.00006076195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001108795,0.0001112898,0.005832382,0.00001368887,0.000002502395,0.000002217964,0.00004403629,0.000004529903,0.9906377,0.0002749149,0.00002440458,0.002941455],"study_design_scores_gemma":[0.0003386191,0.0004212864,0.1160223,0.00002926887,0.000002213294,0.000003000686,0.0002203507,0.000005065247,0.8824371,0.0003333384,0.00009604566,0.00009151139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971449,0.0006397112,0.0000416574,0.0002597159,0.0000197773,0.0002850318,0.00002997697,0.000005944756,0.001573257],"genre_scores_gemma":[0.9993892,0.00004941387,0.000420141,0.00004804312,0.0000427028,0.000009245496,0.00000596521,0.000004260074,0.00003106421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1101899,"threshold_uncertainty_score":0.386577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532879342387218,"score_gpt":0.2790850532357122,"score_spread":0.26375625981184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}