{"id":"W2082605144","doi":"10.1161/circresaha.113.303179","title":"Specific RNA Inhibition of Causal Alleles","year":2014,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Cumberland Pharmaceuticals","keywords":"Allele; Genetics; Biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001652495,0.0005381464,0.0007576575,0.0003448604,0.0007961596,0.000797347,0.0007804095,0.009489357,0.003785538],"category_scores_gemma":[0.004738982,0.0002415797,0.0006206672,0.0002258195,0.001298232,0.0004604406,0.0004701167,0.007256145,0.0011763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006813717,"about_ca_system_score_gemma":0.0004594518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003521761,"about_ca_topic_score_gemma":0.0008100534,"domain_scores_codex":[0.9990081,0.0003938426,0.00008682769,0.0001431754,0.0002083029,0.0001597767],"domain_scores_gemma":[0.9976259,0.00182619,0.0001250279,0.0001595143,0.00009404622,0.0001693996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004259941,0.001097986,0.009369186,0.0006155655,0.0006440381,0.04932756,0.000592684,0.0008419545,0.1381984,0.06147524,0.5087394,0.2248381],"study_design_scores_gemma":[0.004541798,0.003331303,0.01334015,0.0005042194,0.0007775941,0.04492887,0.0004399448,0.004178545,0.1315306,0.04905242,0.7471717,0.0002028555],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.08884477,0.0203235,0.008749038,0.7837459,0.04555937,0.0002264174,0.0005478784,0.0006075034,0.05139565],"genre_scores_gemma":[0.4286357,0.008654967,0.0052616,0.4969903,0.03472824,0.0004013639,0.0002500207,0.0001831641,0.0248947],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009489357,"threshold_uncertainty_score":0.0126639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1583241369104532,"score_gpt":0.3817105877250151,"score_spread":0.2233864508145619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}