{"id":"W2082605144","doi":"10.1161/circresaha.113.303179","title":"Specific RNA Inhibition of Causal Alleles","year":2014,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Cumberland Pharmaceuticals","keywords":"Allele; Genetics; Biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001126956,0.0001660374,0.0005358013,0.0006002823,0.0001329304,0.00002806719,0.00007005232,0.0005193556,0.0002184623],"category_scores_gemma":[0.0002062276,0.0001559326,0.000216961,0.0003822056,0.0003342532,0.00004307862,0.00007636756,0.001547162,0.0001607311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541196,"about_ca_system_score_gemma":0.0001254109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006110205,"about_ca_topic_score_gemma":0.000001989345,"domain_scores_codex":[0.9971375,0.000311506,0.0003742252,0.0003856585,0.001417091,0.0003740136],"domain_scores_gemma":[0.9979935,0.0003439615,0.0001076566,0.0005094217,0.0009896694,0.00005577456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004072769,0.00002361664,0.0007704694,0.0006627493,0.00009859791,0.0002408651,0.0001619386,0.00001223743,0.006828762,0.0001289691,0.9890034,0.002027722],"study_design_scores_gemma":[0.0008168485,0.0001362903,0.02401872,0.000541364,0.00006883752,0.00009041948,0.00007337904,0.0000501968,0.00155848,0.0006129128,0.9718462,0.0001863366],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1082013,0.004739888,0.001466382,0.7729234,0.0007996372,0.002376986,0.00007566031,0.0001509032,0.1092658],"genre_scores_gemma":[0.9539647,0.0005621547,0.0000829464,0.03334574,0.008631947,0.00007543902,0.001043321,0.00006798791,0.002225725],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8457634,"threshold_uncertainty_score":0.6721737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1583241369104532,"score_gpt":0.3817105877250151,"score_spread":0.2233864508145619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}