{"id":"W2082621294","doi":"10.1159/000350528","title":"The TNF-α/Sphingosine-1-Phosphate Signaling Axis Drives Myogenic Responsiveness in Heart Failure","year":2013,"lang":"en","type":"review","venue":"Journal of Vascular Research","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Heart failure; Downregulation and upregulation; Tumor necrosis factor alpha; Vascular resistance; Sphingosine-1-phosphate; Internal medicine; Vasoconstriction; Perfusion; Cardiac output; Endocrinology; Cardiology; Medicine; Vasodilation; Hemodynamics; Sphingosine; Chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000379668,0.0006069182,0.0008806817,0.001366022,0.0002108151,0.0006063826,0.0005020368,0.000691026,0.002039053],"category_scores_gemma":[0.0004687262,0.0001898475,0.0003156039,0.001191517,0.0003182246,0.0008573087,0.0004342516,0.0009946583,0.001381278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003456229,"about_ca_system_score_gemma":0.0008491821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006411661,"about_ca_topic_score_gemma":0.001340855,"domain_scores_codex":[0.9998906,0.00001565839,0.00002399297,0.00001675427,0.00004205978,0.00001098809],"domain_scores_gemma":[0.9997969,0.00006891899,0.00004206578,0.000004808525,0.00006556734,0.00002170054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001075636,0.00007878803,0.0003412489,0.01651381,0.00009420327,0.0002887509,0.00004807887,0.0002630517,0.003384666,0.001595516,0.01613064,0.9611536],"study_design_scores_gemma":[0.00003794794,0.0002217969,0.00355258,0.005377131,0.0002359629,0.003579032,0.0001343834,0.0001846438,0.00160469,0.002077763,0.9829658,0.00002824065],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002195706,0.9987828,0.00009500939,0.00021905,0.0001420045,0.000003736599,0.00001391352,0.000005471846,0.0005184851],"genre_scores_gemma":[0.0008882565,0.9984805,0.0001230904,0.00008853142,0.0001151067,0.000004689636,0.00001624972,7.160917e-7,0.0002829066],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002039053,"threshold_uncertainty_score":0.006821275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08156183725095971,"score_gpt":0.4118593329040095,"score_spread":0.3302974956530498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}