{"id":"W2082622337","doi":"10.1038/nmeth.1973","title":"Derivation of iPSCs in stirred suspension bioreactors","year":2012,"lang":"en","type":"article","venue":"Nature Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Induced pluripotent stem cell; Suspension culture; Cell biology; Bioreactor; Suspension (topology); Biology; Human Induced Pluripotent Stem Cells; Cell culture; In vitro; Germline; Cellular differentiation; Embryonic stem cell; Molecular biology; Chemistry; Cell; Genetics; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174794,0.00008675487,0.0001240596,0.0001014569,0.00001488415,0.000003749455,0.0001268165,0.0003977097,0.00001578456],"category_scores_gemma":[0.0006151454,0.0000753421,0.00004808883,0.0002111823,0.00003692221,0.00000512403,0.00009552562,0.0002542868,0.000002194871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001777033,"about_ca_system_score_gemma":0.00003010382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001409075,"about_ca_topic_score_gemma":0.000008857147,"domain_scores_codex":[0.9989579,0.0003434411,0.0001599478,0.0001595191,0.0001505806,0.0002285952],"domain_scores_gemma":[0.999501,0.00005784713,0.0000612193,0.0002484681,0.00007206302,0.00005941951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005096114,0.0000559535,0.01859837,0.0000185189,0.000009170268,4.665297e-7,0.00002925126,0.000003157421,0.9713049,0.00005376444,0.0004526132,0.00942288],"study_design_scores_gemma":[0.0002246239,0.00004366464,0.07380541,0.000009564505,0.000004031359,0.000003125957,0.00002191411,0.00003288902,0.9058868,0.00004205974,0.01985022,0.00007566395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897367,0.002831531,0.005764164,0.000108541,0.0002861691,0.0001547794,0.00000384584,0.000005237167,0.001108989],"genre_scores_gemma":[0.935008,0.00008418604,0.06446416,0.00004920973,0.0001080775,0.000004414456,0.00005060553,0.00001235812,0.0002189912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06541806,"threshold_uncertainty_score":0.3072362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243097720672561,"score_gpt":0.3981938356537533,"score_spread":0.3738840635864972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}