{"id":"W2082622337","doi":"10.1038/nmeth.1973","title":"Derivation of iPSCs in stirred suspension bioreactors","year":2012,"lang":"en","type":"article","venue":"Nature Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Induced pluripotent stem cell; Suspension culture; Cell biology; Bioreactor; Suspension (topology); Biology; Human Induced Pluripotent Stem Cells; Cell culture; In vitro; Germline; Cellular differentiation; Embryonic stem cell; Molecular biology; Chemistry; Cell; Genetics; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001114757,0.0004437587,0.0006622911,0.00051257,0.0005139893,0.001014722,0.0009844707,0.0005049582,0.001842402],"category_scores_gemma":[0.000439852,0.000423243,0.0007150589,0.0004236442,0.000299,0.000423185,0.0005929942,0.001731821,0.003404832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004272983,"about_ca_system_score_gemma":0.0004146615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006521608,"about_ca_topic_score_gemma":0.00103735,"domain_scores_codex":[0.99941,0.00006534679,0.0001159805,0.0001227655,0.0002091676,0.00007678776],"domain_scores_gemma":[0.9995791,0.00009580331,0.0000441829,0.0001176615,0.00009382861,0.00006945229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006187374,0.00004512383,0.0002985692,0.00004932713,0.00001138059,0.0001351889,0.00008562305,0.0002713173,0.9956149,0.0005089046,0.0001919068,0.002725962],"study_design_scores_gemma":[0.00002033014,0.00008052446,0.001114019,0.00001493319,0.00003175958,0.0001317943,0.000034703,0.001833992,0.9903178,0.0002320971,0.006180482,0.00000755862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6579422,0.002540556,0.2976271,0.0005287916,0.0007013523,0.002645866,0.0099765,0.002078206,0.02595947],"genre_scores_gemma":[0.7756519,0.002024509,0.1718503,0.0003221171,0.0001947773,0.001479715,0.01280559,0.0006808618,0.0349903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842402,"threshold_uncertainty_score":0.006163478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243097720672561,"score_gpt":0.3981938356537533,"score_spread":0.3738840635864972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}