{"id":"W2082633743","doi":"10.1042/bj20060116","title":"Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon β-adrenergic stimulation in normal and failing hearts","year":2006,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Phosphorylation; Protein kinase A; Ryanodine receptor; Stimulation; Ryanodine receptor 2; Isoprenaline; Kinase; Protein phosphorylation; Biology; Chemistry; Internal medicine; Receptor; Endocrinology; Cell biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005775636,0.0001737372,0.0002994504,0.0003992551,0.0001358984,0.00004135389,0.00004141774,0.0001868546,0.00002986894],"category_scores_gemma":[0.0001793343,0.0001394855,0.0001061631,0.0006510516,0.0000358463,0.0001602699,0.00003935096,0.0005603886,0.000006942758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605815,"about_ca_system_score_gemma":0.00007948976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001358442,"about_ca_topic_score_gemma":0.000009021142,"domain_scores_codex":[0.9985668,0.0001525994,0.0004089591,0.0002803715,0.0002657101,0.0003255367],"domain_scores_gemma":[0.9994504,0.0001019582,0.0001188807,0.0001368529,0.00008372594,0.0001081735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002493902,0.00005222069,0.006627165,0.0000183203,0.00001526853,0.00003685062,0.0002267472,0.001152551,0.9875696,0.00003215755,0.0002870473,0.001488199],"study_design_scores_gemma":[0.001327408,0.0001975353,0.08672822,0.0002839243,0.00002528859,0.00009180688,0.00006124973,0.001173404,0.9094951,0.0001131491,0.0003413349,0.0001616355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960566,0.0002915233,0.0001373442,0.002843094,0.0001025127,0.0005006554,0.000005091949,0.00001695593,0.00004628213],"genre_scores_gemma":[0.9982526,0.00002086747,0.0004845851,0.0002701961,0.0006624682,0.00002381964,0.000041634,0.00001872937,0.000225106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08010105,"threshold_uncertainty_score":0.5688055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007240853584730224,"score_gpt":0.2410683956003891,"score_spread":0.2338275420156589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}