{"id":"W2082638106","doi":"10.1091/mbc.e03-02-0069","title":"Critical Role of Src and SHP-2 in sst2 Somatostatin Receptor-mediated Activation of SHP-1 and Inhibition of Cell Proliferation","year":2003,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; Université de Sherbrooke","keywords":"Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; Biology; Cell biology; Tyrosine phosphorylation; Tyrosine-protein kinase CSK; Hyperphosphorylation; Signal transduction; SH2 domain; Phosphorylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002021515,0.00009985916,0.0001843819,0.00005273593,0.00001545117,0.000001822546,0.0000657399,0.0001670223,0.000004284153],"category_scores_gemma":[0.000403318,0.00008623943,0.00003663426,0.00009462688,0.0003059861,0.000005370455,0.00006875615,0.00005960091,1.515799e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004782145,"about_ca_system_score_gemma":0.00004896287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002684152,"about_ca_topic_score_gemma":0.000003674872,"domain_scores_codex":[0.9991072,0.0002205976,0.0003117692,0.0001864141,0.00006580295,0.0001081973],"domain_scores_gemma":[0.9994355,0.00003994094,0.0002078139,0.0001852591,0.000108243,0.00002322102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008023373,0.0001148273,0.005111506,0.0001311977,0.000007932945,1.329373e-7,0.00004997365,0.00001126783,0.9923629,0.001998881,0.00001500798,0.0001161979],"study_design_scores_gemma":[0.0006083331,0.0003189017,0.0009369434,0.00003843091,0.00001109018,0.000001109939,0.00008186819,0.00003155704,0.9964527,0.001401598,0.0000453296,0.00007209136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955159,0.003031671,0.0008811306,0.00005934911,0.00002001887,0.0002664063,0.00006927033,0.00000163596,0.0001546286],"genre_scores_gemma":[0.9978551,0.0001035093,0.001851953,0.00004429893,0.000004420526,0.00001132059,0.000115547,0.000009098569,0.00000469563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004174563,"threshold_uncertainty_score":0.3516742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003399798081953854,"score_gpt":0.2190916420759494,"score_spread":0.2156918439939956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}