{"id":"W2082648748","doi":"10.1016/j.biomaterials.2014.04.079","title":"Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells","year":2014,"lang":"en","type":"article","venue":"Biomaterials","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"RWTH Aachen University; Deutsche Forschungsgemeinschaft; Stem Cell Network","keywords":"Mesenchymal stem cell; Cell biology; DNA methylation; Elasticity (physics); Senescence; dNaM; Cellular differentiation; Population; Self-healing hydrogels; Biology; In vitro; Materials science; Gene expression; Gene; Genetics; Composite material; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107914,0.000158738,0.0004738171,0.0001307352,0.00004724431,0.00003237166,0.0001097524,0.000121558,0.0002329968],"category_scores_gemma":[0.0001364513,0.0001255142,0.00004837364,0.000135459,0.00009700626,0.00006796682,0.0001417637,0.000019669,0.00006036564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003503566,"about_ca_system_score_gemma":0.00004024376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001194684,"about_ca_topic_score_gemma":0.000003154503,"domain_scores_codex":[0.9981645,0.0002958701,0.0004818018,0.0003714162,0.000420411,0.000266007],"domain_scores_gemma":[0.9987336,0.0002748827,0.0002269612,0.0004131901,0.0001750555,0.000176348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001371749,0.00004566983,0.007003238,0.0005564785,0.0000291541,0.00000529188,0.0001221936,2.744279e-7,0.9894136,0.0003640113,0.00004532063,0.002277611],"study_design_scores_gemma":[0.0005433716,0.0003926669,0.04819652,0.0001549133,0.00004194349,0.00002233885,0.00005569657,0.0001147548,0.9498914,0.00005400395,0.0004265519,0.0001058783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966425,0.0000662604,0.001829864,0.0001736601,0.0001725112,0.0005763014,0.0000430719,0.00004527506,0.0004505668],"genre_scores_gemma":[0.9985942,0.00004534897,0.0005960629,0.00001745705,0.0001425692,0.00002049957,0.00001183353,0.00002134187,0.0005506921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04119328,"threshold_uncertainty_score":0.511832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081366662705526,"score_gpt":0.3215680827922775,"score_spread":0.2907544161652222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}