{"id":"W2082648748","doi":"10.1016/j.biomaterials.2014.04.079","title":"Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells","year":2014,"lang":"en","type":"article","venue":"Biomaterials","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"RWTH Aachen University; Deutsche Forschungsgemeinschaft; Stem Cell Network","keywords":"Mesenchymal stem cell; Cell biology; DNA methylation; Elasticity (physics); Senescence; dNaM; Cellular differentiation; Population; Self-healing hydrogels; Biology; In vitro; Materials science; Gene expression; Gene; Genetics; Composite material; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189204,0.0001661893,0.000118968,0.0004206699,0.0001869639,0.0003714929,0.0001064782,0.000226177,0.002606684],"category_scores_gemma":[0.0003826882,0.0002310797,0.0001950817,0.0002472803,0.0002088554,0.000337818,0.0001958046,0.000261616,0.0003471806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351165,"about_ca_system_score_gemma":0.0001568498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007196602,"about_ca_topic_score_gemma":0.0007057489,"domain_scores_codex":[0.999891,0.0000194013,0.00001295851,0.00001918207,0.00003535695,0.0000219685],"domain_scores_gemma":[0.9997774,0.00006290194,0.00005941418,0.00002096838,0.00004265476,0.00003660813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003088224,0.00002308553,0.007361981,0.0000299119,0.00001560503,0.00004038166,0.00009877468,0.0001093884,0.9892657,0.0001350919,0.00003559763,0.00257569],"study_design_scores_gemma":[0.00001298894,0.0004131296,0.1759351,0.00001008175,0.00005328197,0.0004846059,0.000666059,0.00147837,0.8183359,0.0003454218,0.002240583,0.00002451673],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975643,0.0008213521,0.0006078742,0.00003788306,0.00001078393,0.000005847804,0.0002126252,0.000007953922,0.0007313259],"genre_scores_gemma":[0.9981376,0.0003011574,0.0001992799,0.00001614922,0.000004706877,0.000007474844,0.0002185966,0.000005489578,0.001109398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002606684,"threshold_uncertainty_score":0.008720219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081366662705526,"score_gpt":0.3215680827922775,"score_spread":0.2907544161652222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}