{"id":"W2082676302","doi":"10.1038/mt.2010.39","title":"Designer Lipids Advance Systemic siRNA Delivery","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Computational biology; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388326,0.0002164897,0.0001541954,0.00004769068,0.00007156612,0.00003743454,0.000366392,0.0002081243,0.0000753256],"category_scores_gemma":[0.00002304331,0.000197405,0.0001545234,0.00008083475,0.00007281082,0.000006274696,0.00005644589,0.0001765615,0.0001186514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006889567,"about_ca_system_score_gemma":0.00006155962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001536204,"about_ca_topic_score_gemma":0.00001199778,"domain_scores_codex":[0.9988857,0.00006219598,0.0001946022,0.0004131509,0.0001493796,0.0002949936],"domain_scores_gemma":[0.9990692,0.000007078543,0.00006786037,0.0006316298,0.0001295926,0.00009467606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001122052,0.00004504482,0.0005972205,0.000005030975,0.00005910739,0.00001808015,0.00002571162,0.00004975321,0.9829406,0.0001085175,0.0006887442,0.01534997],"study_design_scores_gemma":[0.0005741841,0.0003166714,0.0003184104,0.00001316498,0.000007168376,0.00007592337,0.00002290525,0.00003819725,0.9590219,0.0001161492,0.03921439,0.0002809922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986702,0.003285051,0.008087907,0.00007213496,0.0005350273,0.0002007634,0.00000684051,0.0000295411,0.001080711],"genre_scores_gemma":[0.9952648,0.0009944475,0.001037258,0.001365463,0.0003021847,0.0000434207,0.00004445529,0.00004317459,0.000904819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03852564,"threshold_uncertainty_score":0.8049941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007068983090455629,"score_gpt":0.2340033436944569,"score_spread":0.2269343606040013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}