{"id":"W2082683256","doi":"10.1021/tx400158g","title":"Generation of Guanine–Thymine Cross-Links in Human Cells by One-Electron Oxidation Mechanisms","year":2013,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences","keywords":"Guanine; Thymine; Pyrimidine; DNA; Chemistry; Pyrimidine dimer; HeLa; Covalent bond; Cytosine; DNA damage; Nucleobase; Photochemistry; Nucleotide; Stereochemistry; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167364,0.0002792991,0.0001556323,0.0002535796,0.0001368692,0.0001833054,0.0001783243,0.0003513852,0.001188037],"category_scores_gemma":[0.0002364555,0.000140343,0.0001825719,0.000135732,0.0001693287,0.0001330908,0.0001755414,0.0002414528,0.0003149768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025394,"about_ca_system_score_gemma":0.0001270978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003224254,"about_ca_topic_score_gemma":0.0005192128,"domain_scores_codex":[0.9998631,0.00002737517,0.000005333352,0.00004494764,0.00004289384,0.0000162615],"domain_scores_gemma":[0.999873,0.00004440117,0.00003051843,0.00001735925,0.00002394658,0.00001070252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005892137,0.00001118684,0.0004507541,0.00002687359,0.000005595701,0.00004839867,0.00003116222,0.00006261419,0.9970526,0.00007259655,0.00001927207,0.002160021],"study_design_scores_gemma":[0.000003369877,0.0001203253,0.001690494,0.000002619951,0.000006788738,0.0001813884,0.00001051409,0.0002331351,0.9971424,0.00003582437,0.0005711286,0.000002023746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841613,0.002638764,0.01096635,0.00005394991,0.00001776331,0.00005753825,0.0001954701,0.0000817753,0.001827196],"genre_scores_gemma":[0.989889,0.001183083,0.006153265,0.00003762479,0.000005886894,0.0000315693,0.000251766,0.000008612166,0.002439247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188037,"threshold_uncertainty_score":0.003974378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06868840922517237,"score_gpt":0.3841980438094591,"score_spread":0.3155096345842867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}