{"id":"W2082765258","doi":"10.1159/000052601","title":"Effect of Renin-Angiotensin System Blockade on the Expression of the Angiotensinogen Gene and Induction of Hypertrophy in Rat Kidney Proximal Tubular Cells","year":2001,"lang":"en","type":"article","venue":"Nephron Experimental Nephrology","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Servier (Canada); Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Internal medicine; Endocrinology; Losartan; Renin–angiotensin system; Angiotensin II; Muscle hypertrophy; Kidney; Angiotensin receptor; Renal Hypertrophy; Gene expression; Receptor; ACE inhibitor; Chemistry; Biology; Angiotensin-converting enzyme; Medicine; Gene; Diabetic nephropathy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003288585,0.0004763594,0.0006317288,0.0002231371,0.0001669333,0.0003449558,0.0001892587,0.000195821,0.001649557],"category_scores_gemma":[0.0001643241,0.0001636784,0.000385736,0.0001846528,0.0002241431,0.0002147216,0.0002165562,0.0008322448,0.0003758484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001847407,"about_ca_system_score_gemma":0.000391328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007516519,"about_ca_topic_score_gemma":0.001538949,"domain_scores_codex":[0.9997482,0.00005548766,0.00002790861,0.00003298338,0.00005243625,0.00008308009],"domain_scores_gemma":[0.999719,0.00006908748,0.00004712422,0.00003160146,0.00002922807,0.000104061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007555104,0.0002057413,0.0002664845,0.0000582719,0.00001688568,0.0000695659,0.00002580083,0.00007675667,0.9968697,0.000060404,0.00004639695,0.001548388],"study_design_scores_gemma":[0.00007246313,0.00390376,0.00456339,0.000008338956,0.00004924841,0.000127905,0.00005278335,0.000550874,0.9893011,0.00004239142,0.00131866,0.000009085832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994601,0.002788071,0.0007400559,0.00008589487,0.00009355706,0.00002935955,0.0001619423,0.00007527241,0.001424849],"genre_scores_gemma":[0.9935094,0.002348943,0.001483816,0.00009791609,0.00005380762,0.00004755652,0.000541062,0.00002178694,0.001895764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649557,"threshold_uncertainty_score":0.005518317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009361761168995295,"score_gpt":0.239245536577185,"score_spread":0.2298837754081897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}