{"id":"W2082780252","doi":"10.4161/hv.28549","title":"Effects in the use of a genetically engineered strain of<i>Lactococcus lactis</i>delivering in situ IL-10 as a therapy to treat low-grade colon inflammation","year":2014,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Lactococcus lactis; Genetically engineered; Strain (injury); Genetically modified organism; In situ; Inflammation; Recombinant DNA; Microbiology; Medicine; Biology; Immunology; Bacteria; Chemistry; Internal medicine; Genetics; Lactic acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003306117,0.0002021859,0.0002912955,0.0001353991,0.0000374995,0.00002151743,0.0002230283,0.000200488,0.000006409095],"category_scores_gemma":[0.00004499341,0.0001549587,0.00007878195,0.0002032794,0.00002790975,0.000008314129,0.00002808599,0.0001237321,0.00000308191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002421081,"about_ca_system_score_gemma":0.00004654669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001453642,"about_ca_topic_score_gemma":0.0002304591,"domain_scores_codex":[0.9986209,0.0002927158,0.0004796068,0.0002202675,0.000139703,0.0002468289],"domain_scores_gemma":[0.9992659,0.0001190041,0.000153978,0.0003423336,0.00008380602,0.000034984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003433719,0.0001662403,0.001460459,0.0001275039,0.00004270279,0.000001931671,0.001057625,0.001446976,0.9882606,0.000297755,0.00001025661,0.006784604],"study_design_scores_gemma":[0.004809889,0.002432,0.2800191,0.000296662,0.00003361834,0.000007213815,0.00009714999,0.0002373192,0.7031983,0.0001053954,0.008422558,0.0003407396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977074,0.0006131235,0.0004017656,0.00009139215,0.00004721103,0.0009844565,0.000006275977,0.000008446367,0.000139975],"genre_scores_gemma":[0.9991128,0.000268664,0.0001738063,0.0001884983,0.00006007544,0.00005857074,0.0000315256,0.00003076841,0.00007522688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2850623,"threshold_uncertainty_score":0.6319032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128920782259308,"score_gpt":0.2771812836365809,"score_spread":0.2558920758139878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}