{"id":"W2082812004","doi":"10.1182/blood-2003-05-1540","title":"Developmental stage–specific epigenetic control of human β-globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Cancer Research Society","keywords":"Locus control region; Biology; Epigenetics; Histone; Chromatin; Acetylation; Molecular biology; Promoter; Haematopoiesis; Transgene; Regulation of gene expression; Gene expression; Gene; Cell biology; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009695366,0.00007425368,0.00007923719,0.0001001547,0.00006307052,0.0001341493,0.00004802953,0.00005295294,0.0006590667],"category_scores_gemma":[0.0001158853,0.00009742289,0.00005838629,0.00007708507,0.000106819,0.00008715125,0.0001319034,0.0001467107,0.000166648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000947513,"about_ca_system_score_gemma":0.00007900209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003231825,"about_ca_topic_score_gemma":0.0006725002,"domain_scores_codex":[0.9999593,0.0000060625,0.000002691696,0.00001150002,0.00001104892,0.000009257053],"domain_scores_gemma":[0.9999505,0.00001212575,0.00001227617,0.000008139044,0.000006467019,0.00001053112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005582468,0.000003580015,0.001505491,0.000006860828,0.000002344169,0.00002470578,0.00001974767,0.00002027093,0.9967147,0.00006459953,0.000006804418,0.001574981],"study_design_scores_gemma":[0.00001037885,0.0001991877,0.1368785,0.000006767757,0.0000147648,0.000394047,0.00005184748,0.0004971148,0.8597193,0.0001396696,0.00208514,0.000003319955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968823,0.000792082,0.001340738,0.00001269906,0.000002772573,0.000005697193,0.00008690864,0.00001669982,0.000860111],"genre_scores_gemma":[0.9983328,0.0003607408,0.000518319,0.00001369446,0.000002790954,0.000006935229,0.0001715397,0.000005602368,0.0005875066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006590667,"threshold_uncertainty_score":0.002204835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013480815429866,"score_gpt":0.2316800398865188,"score_spread":0.2181992244566528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}