{"id":"W2082815186","doi":"10.1177/1087057109352902","title":"Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins","year":2009,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"American Heart Association","keywords":"Histone; Epigenetics; Drug discovery; Biology; Computational biology; Protein–protein interaction; Biochemistry; Lysine; Small molecule; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006846645,0.0002262514,0.0003263536,0.0001523713,0.0001154203,0.00004129488,0.0001882269,0.0001560549,0.000004609753],"category_scores_gemma":[0.0004524717,0.0002260805,0.0003000496,0.0001591089,0.00008240012,0.00003351385,0.00003440345,0.00007944184,3.034209e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002085703,"about_ca_system_score_gemma":0.0001459024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004362521,"about_ca_topic_score_gemma":0.00007900578,"domain_scores_codex":[0.9984027,0.000114641,0.0005883934,0.0004267876,0.0001871688,0.0002802826],"domain_scores_gemma":[0.9987077,0.00008415883,0.0004648542,0.0004230942,0.0002424466,0.00007770471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005118198,0.0003058137,0.0009235719,0.0001293147,0.00005920432,2.597073e-7,0.00002676385,0.001395979,0.9887373,0.000160804,0.00002542122,0.007723733],"study_design_scores_gemma":[0.001171974,0.001959284,0.001614202,0.0001520686,0.00005681031,3.296828e-7,0.0000617981,0.001153649,0.9920553,0.0008052801,0.0007229676,0.0002463553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6745968,0.0003077155,0.3237297,0.00007393795,0.00007804559,0.0009282877,0.0002324526,0.000007824919,0.00004518155],"genre_scores_gemma":[0.9609905,0.00001974977,0.03761626,0.00002983528,0.000221012,0.0001239533,0.0007774812,0.0000340102,0.0001871239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2863937,"threshold_uncertainty_score":0.9219296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563758959772746,"score_gpt":0.3127906353779313,"score_spread":0.2871530457802038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}