{"id":"W2082815186","doi":"10.1177/1087057109352902","title":"Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins","year":2009,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"American Heart Association","keywords":"Histone; Epigenetics; Drug discovery; Biology; Computational biology; Protein–protein interaction; Biochemistry; Lysine; Small molecule; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005583437,0.001190328,0.0007425691,0.0004704731,0.0002950199,0.0006064675,0.0007723005,0.001144511,0.001912802],"category_scores_gemma":[0.0004041323,0.0004356229,0.0005921408,0.0003604335,0.0002791271,0.0002687602,0.0003884768,0.001100658,0.001555867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005033042,"about_ca_system_score_gemma":0.0003291872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005278853,"about_ca_topic_score_gemma":0.001271046,"domain_scores_codex":[0.9992865,0.0001339107,0.00004141387,0.00008686414,0.0003454729,0.0001058623],"domain_scores_gemma":[0.9996921,0.0001137307,0.00004865868,0.0000228791,0.00006736719,0.0000553888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001650986,0.0002887703,0.0002656644,0.0001124665,0.00003241372,0.00004773122,0.00001822283,0.0004437715,0.989818,0.0001888442,0.0006957892,0.007923177],"study_design_scores_gemma":[0.0000720761,0.001229974,0.0009328226,0.000007458446,0.00003624394,0.0002237297,0.00000895326,0.003298319,0.989112,0.0000777569,0.004982527,0.00001825807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7402616,0.01816574,0.2084453,0.001777673,0.0006234363,0.002454579,0.002559863,0.001997204,0.0237146],"genre_scores_gemma":[0.8336396,0.01063235,0.1117441,0.001706036,0.0001911691,0.002044399,0.003607823,0.0001271262,0.03630735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001912802,"threshold_uncertainty_score":0.006398976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563758959772746,"score_gpt":0.3127906353779313,"score_spread":0.2871530457802038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}