{"id":"W2082832891","doi":"10.1371/journal.pone.0040146","title":"Tim-3 Negatively Regulates Cytotoxicity in Exhausted CD8+ T Cells in HIV Infection","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Human immunodeficiency virus (HIV); Cytotoxic T cell; CD8; Virology; Biology; Chemistry; Immunology; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123714,0.0002471322,0.0002599031,0.000153775,0.0002242476,0.0004333325,0.000192963,0.000401447,0.001285115],"category_scores_gemma":[0.0001604825,0.0001284691,0.0001885823,0.0001250888,0.0002613497,0.0002714164,0.000254846,0.0007217333,0.0003172776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200217,"about_ca_system_score_gemma":0.0001766461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002247485,"about_ca_topic_score_gemma":0.0002422811,"domain_scores_codex":[0.9998965,0.00002369591,0.000008232688,0.00001101187,0.0000164857,0.00004403223],"domain_scores_gemma":[0.9999435,0.000009460065,0.00001290595,0.00000531401,0.000007546194,0.00002136161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009917325,0.0001431505,0.001457527,0.0001033461,0.000009448972,0.0002998083,0.00006751366,0.0001822521,0.9912876,0.0002430553,0.0001668201,0.005047752],"study_design_scores_gemma":[0.0003024322,0.002359567,0.1108258,0.0001005571,0.0001358373,0.002628862,0.0003540797,0.004047064,0.8704793,0.001245485,0.007480574,0.0000404497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947675,0.003631795,0.0003996613,0.00008990309,0.00002526826,0.00001776146,0.0001121461,0.00004308972,0.0009128577],"genre_scores_gemma":[0.9973302,0.001216181,0.0003701868,0.00008237783,0.00001809052,0.0000285809,0.0001353612,0.000008131679,0.0008110088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285115,"threshold_uncertainty_score":0.004299104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03227381666386041,"score_gpt":0.2241130541166723,"score_spread":0.1918392374528119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}