{"id":"W2082841769","doi":"10.1038/ki.2009.436","title":"Smad3-dependent and -independent pathways are involved in peritoneal membrane injury","year":2009,"lang":"en","type":"article","venue":"Kidney International","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"SMAD; Mesothelial Cell; Epithelial–mesenchymal transition; PI3K/AKT/mTOR pathway; Cancer research; Transforming growth factor beta; Cell biology; Biology; Protein kinase B; Signal transduction; Transforming growth factor; Phosphorylation; Chemistry; Downregulation and upregulation; Endocrinology; Medicine; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186447,0.0001432217,0.0001112914,0.00009007556,0.00003881669,0.00004843057,0.0002459028,0.0001147055,0.00009444288],"category_scores_gemma":[0.0002081393,0.0001495742,0.00004905057,0.00003899916,0.00003736448,0.000008906066,0.00009782473,0.0001072547,0.00001189712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004004559,"about_ca_system_score_gemma":0.0001166636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001884588,"about_ca_topic_score_gemma":0.00004146622,"domain_scores_codex":[0.9989609,0.00003372986,0.0002207431,0.0003470701,0.0002625779,0.0001749438],"domain_scores_gemma":[0.9994854,0.000007059254,0.00008011032,0.0001757107,0.00007088463,0.0001808179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003065291,0.0004050331,0.06245913,0.00001841144,0.00007610042,0.00005428086,0.0001523354,0.00006766294,0.9282449,0.0003660151,0.005255662,0.002593902],"study_design_scores_gemma":[0.00253192,0.0003075236,0.2107174,0.0001284176,0.00002254401,0.00003897386,0.0002724133,0.0004519367,0.7509695,0.0006549005,0.03330537,0.0005990818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996666,0.0002547522,0.00009445657,0.001068757,0.0003225694,0.0001094284,0.0001370817,0.00002080199,0.001326185],"genre_scores_gemma":[0.9970474,0.00005958819,0.0003144465,0.001580698,0.0003239865,0.00001573169,0.0003022616,0.00001258191,0.0003433032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1772754,"threshold_uncertainty_score":0.6099458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006541368725976,"score_gpt":0.2465112534559266,"score_spread":0.2364458397686668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}