{"id":"W2082842533","doi":"10.1016/j.nucmedbio.2006.11.001","title":"Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [18F]F-PHNO","year":2007,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Radiosynthesis; Biodistribution; Ex vivo; Chemistry; Dopamine receptor D2; In vivo; In vitro; Pharmacology; Dopamine; Dopamine receptor D3; Receptor; Neuroscience; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001105045,0.0001869183,0.0004342553,0.0004525862,0.00005753507,0.000007758042,0.0001197439,0.000134324,0.0001516308],"category_scores_gemma":[0.001225852,0.0001457421,0.00003320732,0.0004934036,0.001320674,0.0001028765,0.00003664731,0.000141216,0.000001956315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002433057,"about_ca_system_score_gemma":0.0000200125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001563971,"about_ca_topic_score_gemma":0.000006590733,"domain_scores_codex":[0.998309,0.0003007737,0.0004776322,0.000439203,0.000223255,0.0002501021],"domain_scores_gemma":[0.9989183,0.0004998498,0.0002084663,0.0001713059,0.0001042823,0.00009782766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003583807,0.00007382632,0.007935966,0.0000501659,0.000006089256,0.000004985287,0.000204994,7.145147e-8,0.9567569,0.0001785332,0.00003252077,0.03439751],"study_design_scores_gemma":[0.001217323,0.0007130083,0.02513945,0.0001570626,0.00007765156,0.0001121425,0.0002917787,0.00006171829,0.9679116,0.0001215554,0.004027002,0.0001696975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976896,0.0007895564,0.000005195523,0.0007384658,0.0001519433,0.0003584231,0.00005676152,0.00002959345,0.0001804673],"genre_scores_gemma":[0.9986453,0.0009976745,0.0001136489,0.0001717926,0.00004171585,0.000005566893,0.000006781653,0.00001378333,0.000003718151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03422781,"threshold_uncertainty_score":0.5943192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06550089603235407,"score_gpt":0.3343548837903286,"score_spread":0.2688539877579745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}