{"id":"W2082857033","doi":"10.1038/sj.gt.3302836","title":"Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice","year":2006,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Fusion protein; Incretin; Glucose homeostasis; Biology; Insulin; Glucagon-like peptide-1; Glucagon; Fusion gene; Peptide; Endocrinology; Internal medicine; Glucagon-like peptide 1 receptor; Cell biology; Receptor; Diabetes mellitus; Type 2 diabetes; Gene; Biochemistry; Insulin resistance; Recombinant DNA; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003438006,0.0003112821,0.000668078,0.0002807332,0.00007996586,0.00002036803,0.0001299459,0.0001611942,0.0005142748],"category_scores_gemma":[0.00003198471,0.0002550413,0.0001659324,0.0004608793,0.0001695219,0.0001086236,0.00002727653,0.00014531,0.0000143127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008307942,"about_ca_system_score_gemma":0.0001794136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005033654,"about_ca_topic_score_gemma":0.00001534445,"domain_scores_codex":[0.9981681,0.00008365496,0.0005861517,0.0003574823,0.0003466085,0.0004579662],"domain_scores_gemma":[0.9989778,0.0001431891,0.0002234385,0.0003985927,0.0001536444,0.00010329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004066433,0.0003880873,0.0812272,0.00002419178,0.00009335399,0.000003856082,0.00018689,0.00008384369,0.9060257,0.00004045642,0.00006317237,0.01145657],"study_design_scores_gemma":[0.008508561,0.0004490632,0.113784,0.0000983171,0.00002486696,0.00001766991,0.00006660513,0.0008442267,0.8742746,0.0002108311,0.001478659,0.0002425839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851603,0.01278364,0.0002663356,0.0001600031,0.0002688781,0.0005291869,0.0000672661,0.00006762761,0.0006967677],"genre_scores_gemma":[0.9873201,0.00140797,0.009633448,0.001068737,0.000301714,0.00002114722,0.00006373418,0.00004841863,0.0001347507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03255681,"threshold_uncertainty_score":0.9999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03750412926097298,"score_gpt":0.2708164528455693,"score_spread":0.2333123235845963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}