{"id":"W2082860583","doi":"10.1007/s12031-013-0158-6","title":"Implication of the ERK/MAPK Pathway in Antipsychotics-induced Dopamine D2 Receptor Upregulation and in the Preventive Effects of (±)-α-lipoic acid in SH-SY5Y Neuroblastoma Cells","year":2013,"lang":"en","type":"article","venue":"Journal of Molecular Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Novartis Pharma; Canada Research Chairs; Université de Sherbrooke","keywords":"MAPK/ERK pathway; Haloperidol; Downregulation and upregulation; Protein kinase B; Dopamine receptor D2; Pharmacology; Chemistry; Lipoic acid; Endocrinology; Medicine; Dopamine; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012376,0.0003543624,0.0002386595,0.0001739495,0.0001979714,0.0002074093,0.0001521009,0.0002577625,0.001329011],"category_scores_gemma":[0.000087556,0.0001746357,0.0003151165,0.0001318264,0.0002040268,0.0003186077,0.0001622601,0.0005488908,0.0002905661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247161,"about_ca_system_score_gemma":0.0003854289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128812,"about_ca_topic_score_gemma":0.001444464,"domain_scores_codex":[0.9999233,0.00001162591,0.000008810681,0.000009053644,0.00001514905,0.00003202762],"domain_scores_gemma":[0.9999489,0.000005161572,0.00001353063,0.000006742387,0.000009492253,0.00001616119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001481938,0.00009101703,0.0002610136,0.00006241607,0.000007691424,0.0001577258,0.00002076934,0.00006622445,0.9965124,0.0001686052,0.00004053033,0.001129763],"study_design_scores_gemma":[0.0001015192,0.0006652492,0.009520318,0.00001086314,0.00004338793,0.0002536908,0.00009760349,0.0007216095,0.9871637,0.0001617068,0.001252012,0.000008318677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968419,0.001207122,0.0005489609,0.0001250491,0.00003228589,0.00001405554,0.0003556615,0.00003483787,0.0008400612],"genre_scores_gemma":[0.9965615,0.001120831,0.0005585683,0.00003169952,0.000006930957,0.0000256665,0.0002309809,0.000005591175,0.001458211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329011,"threshold_uncertainty_score":0.00444597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006380761549800378,"score_gpt":0.2225190027919646,"score_spread":0.2161382412421642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}