{"id":"W2082872110","doi":"10.1371/journal.pone.0037724","title":"Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Genome Canada; KU Leuven; Ontario Genomics; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Penciclovir; Nucleoside analogue; Chemistry; Biochemistry; Nucleoside; Nucleobase; Stereochemistry; Biology; DNA; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001923927,0.0003957881,0.0004549159,0.000770244,0.0001175697,0.0003236345,0.0001461792,0.0003181136,0.002484025],"category_scores_gemma":[0.0002636394,0.0001336509,0.0002487985,0.0007599076,0.000084435,0.0001659301,0.0002576659,0.0002473322,0.0005754497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222466,"about_ca_system_score_gemma":0.0002363232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004942152,"about_ca_topic_score_gemma":0.0008792308,"domain_scores_codex":[0.9997768,0.00003287444,0.00001658589,0.00004717897,0.0000903844,0.00003630823],"domain_scores_gemma":[0.9998535,0.00003249852,0.00003641557,0.000008864407,0.00004423471,0.00002442845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004228094,0.0001061483,0.003446724,0.0002124569,0.00003106735,0.0001208795,0.00001683683,0.0008846514,0.9786268,0.00005400409,0.000157795,0.01591979],"study_design_scores_gemma":[0.00006281398,0.003704683,0.0393316,0.00003632289,0.0002262467,0.001646402,0.0001058198,0.006579877,0.9357812,0.0001548813,0.012343,0.00002712058],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980258,0.007428661,0.004266662,0.0000925588,0.00002062841,0.0001752813,0.003432944,0.0001776752,0.004147425],"genre_scores_gemma":[0.9764424,0.004045263,0.00866562,0.000130693,0.00001448252,0.0001747536,0.006760219,0.0000305385,0.003736136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002484025,"threshold_uncertainty_score":0.008309901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02914390723568288,"score_gpt":0.2463618330308295,"score_spread":0.2172179257951466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}