{"id":"W2082872110","doi":"10.1371/journal.pone.0037724","title":"Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Genome Canada; KU Leuven; Ontario Genomics; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Penciclovir; Nucleoside analogue; Chemistry; Biochemistry; Nucleoside; Nucleobase; Stereochemistry; Biology; DNA; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809699,0.000124242,0.0001978573,0.00003709426,0.0000572771,0.00000909594,0.000156521,0.00009147749,0.00001352009],"category_scores_gemma":[0.00009169946,0.00008463603,0.00006989013,0.0001014424,0.0001932015,0.00000824049,0.0001310316,0.0001354305,7.720306e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005980544,"about_ca_system_score_gemma":0.00003666328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005417726,"about_ca_topic_score_gemma":0.0000156909,"domain_scores_codex":[0.999064,0.00008620939,0.0001941982,0.0002005087,0.0002369457,0.0002181115],"domain_scores_gemma":[0.999301,0.00001485706,0.000132424,0.0003395101,0.0001295461,0.00008270454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001133126,0.0007137961,0.007281206,0.0001435232,0.000154748,3.015125e-7,0.00003071984,0.000001618576,0.9909437,0.0003456945,0.00002189099,0.0002494814],"study_design_scores_gemma":[0.0004892346,0.0001374485,0.005832303,0.00008336086,0.00009271235,0.000001390423,0.00005392616,0.00006307202,0.9928648,0.00001617755,0.0002601797,0.0001054327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984252,0.0006262246,0.0000777621,0.0001337192,0.00001279629,0.0002710793,0.00002296947,0.000006550619,0.0004236533],"genre_scores_gemma":[0.9968848,0.00002355243,0.002777295,0.0001067857,0.00006658446,0.0000185771,0.00003378015,0.00002295937,0.00006565399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002699533,"threshold_uncertainty_score":0.3451357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02914390723568288,"score_gpt":0.2463618330308295,"score_spread":0.2172179257951466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}