{"id":"W2082909867","doi":"10.1016/j.str.2013.01.015","title":"Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A","year":2013,"lang":"en","type":"article","venue":"Structure","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"EIF4G; Isothermal titration calorimetry; eIF4A; Eukaryotic translation; Internal ribosome entry site; EIF4E; Biology; Biophysics; Binding domain; Cell biology; RNA; Binding site; Crystallography; Translation (biology); Chemistry; Ribosome; Genetics; Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002704868,0.00009746213,0.0001201964,0.00003384297,0.00005660122,0.00001783698,0.0001160522,0.00008720717,0.0001779036],"category_scores_gemma":[0.00001447723,0.00005368639,0.00005665939,0.0001411615,0.00003692735,0.00000529025,0.00004987285,0.00005449036,4.932794e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003711286,"about_ca_system_score_gemma":0.0000118175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003811596,"about_ca_topic_score_gemma":0.0001067019,"domain_scores_codex":[0.9995022,0.00004726387,0.00009509597,0.0001712402,0.00008925291,0.00009491998],"domain_scores_gemma":[0.9995997,0.000005848303,0.00008931892,0.000220671,0.00005491726,0.00002952336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002643452,0.000001352709,0.003101089,0.000007952614,0.0002684678,1.512377e-7,0.00007903274,0.00007065808,0.9946517,0.0002165237,0.00004020579,0.001536474],"study_design_scores_gemma":[0.0001919788,0.00009486112,0.08125437,0.000009880555,0.0002014037,0.00001574679,0.0001758355,0.000168735,0.9159739,0.001169542,0.000612848,0.0001308768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991875,0.000192258,0.00008331204,0.0001228387,0.0000707151,0.000162126,0.00002710242,0.000002807493,0.0001513756],"genre_scores_gemma":[0.9991482,0.000008062269,0.0005430604,0.00007670297,0.00004646789,0.000006124454,0.00002275353,0.000007404223,0.0001411934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07867774,"threshold_uncertainty_score":0.2189268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004454669424656687,"score_gpt":0.2107081257147012,"score_spread":0.2062534562900445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}