{"id":"W2082909867","doi":"10.1016/j.str.2013.01.015","title":"Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A","year":2013,"lang":"en","type":"article","venue":"Structure","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"EIF4G; Isothermal titration calorimetry; eIF4A; Eukaryotic translation; Internal ribosome entry site; EIF4E; Biology; Biophysics; Binding domain; Cell biology; RNA; Binding site; Crystallography; Translation (biology); Chemistry; Ribosome; Genetics; Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278562,0.0003362995,0.0002392708,0.0001487899,0.0003445875,0.0001861122,0.0004567437,0.0002757259,0.000939144],"category_scores_gemma":[0.0002553889,0.0001198566,0.0002585459,0.0001812538,0.000182986,0.000196194,0.0001776274,0.000509247,0.0001420467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007615337,"about_ca_system_score_gemma":0.0002393708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003353402,"about_ca_topic_score_gemma":0.002915546,"domain_scores_codex":[0.9999094,0.00001490152,0.000004515007,0.00001471632,0.00003042236,0.00002610231],"domain_scores_gemma":[0.9999189,0.00002290159,0.0000172286,0.000003638954,0.00001357505,0.00002370069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001174047,0.0003330418,0.006013216,0.0002336955,0.00007477974,0.0007463416,0.0001460304,0.005411783,0.9779664,0.001171615,0.0006093374,0.006119804],"study_design_scores_gemma":[0.0002335036,0.0008313279,0.0870019,0.00006443801,0.0001529366,0.001115336,0.0006895021,0.1112874,0.7889219,0.000559405,0.009060222,0.00008208934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982976,0.0004398602,0.0005568186,0.00005971644,0.00001014271,0.000005539132,0.0001388144,0.0000131687,0.0004784188],"genre_scores_gemma":[0.9982361,0.0001681163,0.0006825114,0.00002864716,0.000004428468,0.000004692053,0.0005246623,0.000004209489,0.0003467722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003353402,"threshold_uncertainty_score":0.006667793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004454669424656687,"score_gpt":0.2107081257147012,"score_spread":0.2062534562900445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}