{"id":"W2082922083","doi":"10.1038/npre.2009.3419.1","title":"Technical Note: The Use of RNA-interference as a Tool to Find Proteins Involved in Melanosome Formation or Transport","year":2009,"lang":"en","type":"preprint","venue":"Nature Precedings","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; Hospital for Sick Children","keywords":"Melanosome; Gene knockdown; Cell biology; RNA interference; Tyrosinase; Biology; Melanocyte; Melanin; Chemistry; Gene; RNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009873863,0.001972974,0.001640516,0.002221295,0.001781367,0.001325915,0.001556655,0.001758836,0.02593191],"category_scores_gemma":[0.008355411,0.001506838,0.002601533,0.001120798,0.001661901,0.001272928,0.00232409,0.003228232,0.02735027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000427113,"about_ca_system_score_gemma":0.001571805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000587234,"about_ca_topic_score_gemma":0.001406573,"domain_scores_codex":[0.9899402,0.002961626,0.001694281,0.001397541,0.003444396,0.0005619437],"domain_scores_gemma":[0.985363,0.00556961,0.0008539507,0.00370349,0.003678627,0.0008312537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004035117,0.0003053401,0.0006975967,0.0008686307,0.00008376523,0.0009361407,0.0004201121,0.0002264577,0.956102,0.002221459,0.01505293,0.02268217],"study_design_scores_gemma":[0.0003199871,0.001058241,0.003167738,0.0001569415,0.0002575867,0.007397352,0.0001220411,0.002413213,0.7541692,0.001093575,0.229709,0.0001351236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.06702924,0.007527689,0.8413622,0.009451848,0.01554822,0.01503395,0.006708972,0.01363117,0.0237067],"genre_scores_gemma":[0.1157995,0.008384109,0.7225905,0.003914444,0.002206762,0.02174788,0.01673227,0.006594167,0.1020304],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.02593191,"threshold_uncertainty_score":0.08675081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466549615650596,"score_gpt":0.2972212111207946,"score_spread":0.2725557149642887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}