{"id":"W2082923538","doi":"10.1124/dmd.105.008029","title":"INDUCTION AND RECOVERY TIME COURSE OF RAT BRAIN CYP2E1 AFTER NICOTINE TREATMENT","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Nicotine; CYP2E1; Pharmacology; Chemistry; Toxicity; Internal medicine; Endocrinology; Medicine; Anesthesia; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071119,0.000142385,0.000180966,0.00003289884,0.00004395772,0.0000153787,0.00002765125,0.00007933883,0.00001629263],"category_scores_gemma":[0.000008090487,0.0001187268,0.00005417979,0.0000501554,0.00006456421,0.00001206918,0.00003700454,0.00003275348,0.000003162138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000692706,"about_ca_system_score_gemma":0.00001880529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008542512,"about_ca_topic_score_gemma":0.00003258646,"domain_scores_codex":[0.9993131,0.00006977135,0.0001806043,0.0002498073,0.00006497272,0.0001218129],"domain_scores_gemma":[0.9996807,0.00001115051,0.00008239834,0.0001446682,0.00003854353,0.00004251931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003426939,0.0003863943,0.004352418,0.00001775653,0.00006460712,2.859135e-7,0.0001053355,0.00001191134,0.9758877,0.00008435101,0.002884251,0.01586234],"study_design_scores_gemma":[0.002573319,0.0003049645,0.08114614,0.00002299643,0.0002310773,0.00002868554,0.0001144593,0.00004632912,0.8926796,0.0001900575,0.02234321,0.0003191463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928646,0.006145267,0.0001140719,0.0002717276,0.0001548861,0.0001878001,0.00005526334,0.000008230485,0.0001981685],"genre_scores_gemma":[0.9967995,0.0006094032,0.0002076905,0.0000638375,0.0003726498,0.00002564377,0.0003856485,0.0000140351,0.001521593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08320804,"threshold_uncertainty_score":0.4841538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002347852849154199,"score_gpt":0.2117239402352839,"score_spread":0.2093760873861297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}