{"id":"W2082923538","doi":"10.1124/dmd.105.008029","title":"INDUCTION AND RECOVERY TIME COURSE OF RAT BRAIN CYP2E1 AFTER NICOTINE TREATMENT","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Nicotine; CYP2E1; Pharmacology; Chemistry; Toxicity; Internal medicine; Endocrinology; Medicine; Anesthesia; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302249,0.0005408048,0.0008029324,0.0006416778,0.0003280719,0.0004422317,0.0004462794,0.0004744622,0.004274168],"category_scores_gemma":[0.0005129984,0.0003354604,0.0007851337,0.0006262569,0.0006041719,0.0007117019,0.0002762759,0.001300079,0.001148375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005967814,"about_ca_system_score_gemma":0.0005245346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003076879,"about_ca_topic_score_gemma":0.004592037,"domain_scores_codex":[0.9997701,0.00002036936,0.00001404272,0.00006231533,0.00003693674,0.00009625289],"domain_scores_gemma":[0.9995854,0.0000886858,0.00006515122,0.00008225485,0.00006576654,0.0001126115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009985684,0.0003713174,0.001686727,0.00008260493,0.00008303396,0.0002867529,0.0001321163,0.0001922862,0.9759322,0.0004478515,0.0003217639,0.01047755],"study_design_scores_gemma":[0.00004850169,0.001169038,0.01718505,0.00000666144,0.00008007176,0.0002024258,0.00008530238,0.0009062981,0.9789272,0.0001662425,0.001205874,0.00001737478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857949,0.003204765,0.004489789,0.0002256111,0.0001911361,0.00007185522,0.001720822,0.0002849805,0.00401627],"genre_scores_gemma":[0.9784529,0.0011989,0.001727871,0.0001054486,0.00007154404,0.0001354509,0.002854096,0.00008862111,0.01536519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004274168,"threshold_uncertainty_score":0.0142985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002347852849154199,"score_gpt":0.2117239402352839,"score_spread":0.2093760873861297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}