{"id":"W2082947145","doi":"10.1038/ng.714","title":"Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies","year":2010,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":511,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Danmarks Grundforskningsfond; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; March of Dimes Foundation; Helmholtz Zentrum München; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; U.S. Public Health Service; Centre for Medical Systems Biology; Hjartavernd; University of Bristol; Egmont Fonden; Amgen; Chinese Society of Clinical Oncology; Fondation Leenaards; Compagnia di San Paolo; Augustinus Fonden; National Institute on Drug Abuse; Hjärt-Lungfonden; Fondazione Cariplo; Vetenskapsrådet; Scottish Government; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Ministero della Salute; European Regional Development Fund; Bundesministerium für Bildung und Forschung; Cancer Research UK; Wellcome Trust; Münchner Zentrum für Gesundheitswissenschaften; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Foundation; Svenska Läkaresällskapet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute on Minority Health and Health Disparities; European Commission; National Cancer Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; National Science Foundation; American Heart Association; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation International","keywords":"Biology; Menarche; Genome-wide association study; Genetics; Gene; Genetic association; Body mass index; Genome; Genotype; Single-nucleotide polymorphism; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001777135,0.001434957,0.003395444,0.00243903,0.0002281764,0.00114921,0.001362853,0.001063421,0.001604012],"category_scores_gemma":[0.002469281,0.0004476517,0.002355233,0.004039484,0.0003747617,0.00067634,0.0007309337,0.0007436731,0.0003550632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004854241,"about_ca_system_score_gemma":0.001398404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002633297,"about_ca_topic_score_gemma":0.005861828,"domain_scores_codex":[0.9993104,0.0001441225,0.0001161573,0.0002304672,0.0001529634,0.0000459519],"domain_scores_gemma":[0.9981342,0.001324578,0.0002633221,0.00006253029,0.000148984,0.00006646127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00189051,0.0001061738,0.0816295,0.03435365,0.03039311,0.003730944,0.000244741,0.00129064,0.00916235,0.001027265,0.0110199,0.8251513],"study_design_scores_gemma":[0.001100666,0.0008816384,0.5703524,0.0136959,0.1465125,0.02217228,0.0008046022,0.001409618,0.004992164,0.008829266,0.228833,0.0004160446],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00514318,0.9933762,0.0006257367,0.0003071297,0.00007993382,0.000006121526,0.0002187027,0.00001760967,0.0002253587],"genre_scores_gemma":[0.03999025,0.9562249,0.002093405,0.0003652456,0.000216751,0.00002011521,0.0007667027,0.000009767985,0.0003128924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003395444,"threshold_uncertainty_score":0.00939846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.114295855458125,"score_gpt":0.3929088654261171,"score_spread":0.2786130099679922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}