{"id":"W2082981677","doi":"10.1002/cmdc.200900240","title":"<i>N</i>‐(Anilinoethyl)amides: Design and Synthesis of Metabolically Stable, Selective Melatonin Receptor Ligands","year":2009,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research; Ministero dell'Università e della Ricerca","keywords":"Acetamide; Partial agonist; Receptor; Agonist; Microsome; In vivo; Intrinsic activity; Melatonin; In vitro; Chemistry; S9 fraction; Melatonin receptor; Potency; Biochemistry; Pharmacology; Stereochemistry; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758926,0.0003590654,0.0001910411,0.0001235207,0.00007935145,0.0001866529,0.000326545,0.0002515269,0.0009352227],"category_scores_gemma":[0.0001139192,0.0001132953,0.0001594404,0.0001290862,0.0001037368,0.0002514436,0.0001685224,0.0002449625,0.0005713225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001731139,"about_ca_system_score_gemma":0.0001174735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001693084,"about_ca_topic_score_gemma":0.0003249407,"domain_scores_codex":[0.9999319,0.00001701998,0.000007080546,0.00001488738,0.00001257431,0.00001663837],"domain_scores_gemma":[0.9999421,0.000004928429,0.00002331935,0.000004169155,0.000007901834,0.00001765009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001656844,0.00004640527,0.0001072086,0.0001082872,0.000009793682,0.0001111817,0.00002015425,0.0005641082,0.9916186,0.0003533543,0.0001090231,0.006786121],"study_design_scores_gemma":[0.0001012108,0.001563112,0.001293791,0.00001025119,0.000025704,0.000579213,0.00002242227,0.001474387,0.9828838,0.00009473587,0.01193566,0.00001576399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675067,0.005363229,0.01991028,0.000134781,0.00005663942,0.0002086554,0.0006116433,0.0001373798,0.006070736],"genre_scores_gemma":[0.9682344,0.005007216,0.02105669,0.0001504382,0.00003737406,0.0001946338,0.0007287273,0.00003402367,0.004556398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009352227,"threshold_uncertainty_score":0.003128648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02276762489961097,"score_gpt":0.2457797814732893,"score_spread":0.2230121565736783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}