{"id":"W2082994485","doi":"10.1016/j.tibs.2009.02.001","title":"On the origin of the cap-dependent initiation of translation in eukaryotes","year":2009,"lang":"en","type":"article","venue":"Trends in Biochemical Sciences","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"EIF4E; Eukaryotic translation; Eukaryotic initiation factor; Internal ribosome entry site; Ribosomal binding site; Translation (biology); Initiation factor; Biology; Ribosome; EIF4A1; Shine-Dalgarno sequence; Intron; Protein biosynthesis; Eukaryotic translation initiation factor 4 gamma; Cell biology; Computational biology; Genetics; Messenger RNA; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003990586,0.00005703288,0.00007009658,0.00004872696,0.00002456484,0.000004590978,0.0002557996,0.00006577471,0.00002469933],"category_scores_gemma":[0.00009066042,0.00003096683,0.00004014541,0.0003269483,0.000130376,0.000003042695,0.00001360663,0.00004421779,2.947155e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005652013,"about_ca_system_score_gemma":0.00001962059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002290379,"about_ca_topic_score_gemma":0.00002689796,"domain_scores_codex":[0.9993489,0.00007030176,0.000168089,0.0001436427,0.0001734881,0.00009555657],"domain_scores_gemma":[0.9997327,0.00004965303,0.00006988366,0.0001268175,0.00001057512,0.00001039771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002163942,0.00004379917,0.0008151832,0.000001472919,0.000001006566,6.899693e-8,0.00007111476,0.00004855776,0.9869205,0.002161108,0.00002820256,0.009887373],"study_design_scores_gemma":[0.0001097573,0.0001244836,0.008455728,0.00002475973,0.00000162732,4.091998e-7,0.00003942286,0.00005503292,0.987546,0.00358055,0.00002117072,0.00004109794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961445,0.0002241277,0.00004058681,0.0009713838,0.00002995117,0.00005973578,0.000003456764,0.000001236539,0.002525025],"genre_scores_gemma":[0.9996977,0.00002489768,0.0001426427,0.0000895178,0.0000145229,0.000004006419,0.000002664251,0.000001377038,0.00002271353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009846275,"threshold_uncertainty_score":0.1262791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03787581836475395,"score_gpt":0.2976077996606128,"score_spread":0.2597319812958589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}