{"id":"W2083002978","doi":"10.1371/journal.ppat.1003618","title":"A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1006,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Aids Fonds; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Epitope; Gp41; Monoclonal antibody; Virology; Epitope mapping; Chemistry; Antibody; Neutralizing antibody; Conformational epitope; Viral envelope; Glycoprotein; Virus; Biology; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577718,0.0004303965,0.0001557976,0.0001398007,0.0001062248,0.0002467313,0.0002773945,0.0003037366,0.0007155836],"category_scores_gemma":[0.0001013077,0.0001315254,0.00022312,0.0001210925,0.0001553257,0.0001590803,0.0001645006,0.0007174579,0.000387004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003792209,"about_ca_system_score_gemma":0.0001660442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006363483,"about_ca_topic_score_gemma":0.0008377359,"domain_scores_codex":[0.9998851,0.00001614405,0.00001156299,0.00001937308,0.00004949968,0.00001839876],"domain_scores_gemma":[0.9999449,0.000007003755,0.0000212505,0.000007861508,0.000007299788,0.00001167104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000226808,0.00001522904,0.00008896377,0.000008748739,0.000002649592,0.00001961776,0.00000580961,0.00007350863,0.9991323,0.00004274806,0.00002337045,0.0005644219],"study_design_scores_gemma":[0.0000146053,0.0004285178,0.001584374,0.000002594196,0.00001895611,0.0003109858,0.00001490237,0.0008600533,0.9941903,0.00002513788,0.002544638,0.000004913285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914554,0.0004656872,0.00600788,0.00009163307,0.00002534723,0.00009069127,0.0005301212,0.00004997674,0.001283257],"genre_scores_gemma":[0.9675808,0.0006953611,0.02482979,0.0001012184,0.00001087122,0.00006664451,0.002682235,0.00003216203,0.004000906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007155836,"threshold_uncertainty_score":0.00275147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0758215417074364,"score_gpt":0.2744256858085815,"score_spread":0.1986041441011451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}