{"id":"W2083040927","doi":"10.1021/mp900258z","title":"Interplay of Transporters and Enzymes in Drug and Metabolite Processing","year":2009,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Transporter; Drug metabolism; Metabolism; Biology; Enzyme; Secretion; Metabolite; Drug; Catabolism; Biochemistry; Cell; Metabolic pathway; Cell biology; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006233696,0.0007235873,0.001268227,0.0005337279,0.0003298249,0.001833945,0.0006960525,0.001206382,0.001545281],"category_scores_gemma":[0.0004810299,0.0003928737,0.001161017,0.0007757823,0.0006073594,0.002271727,0.0006707541,0.001022775,0.001087895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007639457,"about_ca_system_score_gemma":0.0008265589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000948436,"about_ca_topic_score_gemma":0.0007355827,"domain_scores_codex":[0.9995414,0.0001347992,0.00005290056,0.0001027771,0.0001005044,0.00006768505],"domain_scores_gemma":[0.9998285,0.00006355652,0.0000337808,0.00001188717,0.00004562694,0.00001668463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001262568,0.0001813513,0.005867079,0.02425844,0.001119636,0.005045665,0.0008030301,0.0338873,0.3505129,0.113591,0.01344752,0.4500235],"study_design_scores_gemma":[0.00006891599,0.001114422,0.007781794,0.001113186,0.0009942446,0.00846436,0.0006214666,0.02669932,0.1673039,0.04702457,0.7385919,0.0002220195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04928952,0.8519127,0.07861385,0.004361601,0.00125636,0.00008050882,0.0004066647,0.0004548682,0.01362384],"genre_scores_gemma":[0.2244851,0.7430182,0.02024643,0.00132326,0.0006950731,0.0000957388,0.0005201921,0.00009589305,0.009520118],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001833945,"threshold_uncertainty_score":0.005542874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02589455334448843,"score_gpt":0.37239467721724,"score_spread":0.3465001238727516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}