{"id":"W2083055539","doi":"10.1016/j.brainres.2014.02.015","title":"Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients","year":2014,"lang":"en","type":"article","venue":"Brain Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Siragusa Foundation; National Institute on Aging; ALS Association","keywords":"CpG site; C9orf72; DNA methylation; Epigenetics; Biology; Frontotemporal dementia; Amyotrophic lateral sclerosis; Methylation; Trinucleotide repeat expansion; Molecular biology; Genetics; Gene; Gene expression; Medicine; Dementia; Pathology; Disease; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003907668,0.00007068599,0.0002203245,0.0003475102,0.00005019071,0.00001227554,0.0002452152,0.00009477729,0.0001703333],"category_scores_gemma":[0.002335194,0.00004663093,0.00004640296,0.000852584,0.0002175235,0.00008458414,0.00009476204,0.000325392,0.00002477012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006201743,"about_ca_system_score_gemma":0.0000841831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001810372,"about_ca_topic_score_gemma":0.00001516589,"domain_scores_codex":[0.9966803,0.001070993,0.0003567371,0.0001890043,0.001384005,0.0003189657],"domain_scores_gemma":[0.9981911,0.0007328023,0.00007936611,0.000397624,0.0005370944,0.00006198683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002049645,0.0003438133,0.118514,0.0001719981,0.000009943199,9.838556e-7,0.0009015878,0.000001643811,0.8554075,0.0004986915,0.000284258,0.02366058],"study_design_scores_gemma":[0.001071264,0.0005419742,0.9725419,0.0001155287,0.000002574598,5.875661e-7,0.00005481222,0.0006497854,0.02360734,0.000243668,0.001131238,0.00003936352],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928867,0.000007356027,0.00005211655,0.004179745,0.00002092888,0.0007877488,0.00000754948,0.000005466706,0.002052338],"genre_scores_gemma":[0.9991713,0.00002498944,0.00006078834,0.0001132982,0.00007041109,0.00003285065,0.00008037235,0.00001417376,0.0004317955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8540279,"threshold_uncertainty_score":0.2795614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07040991890515164,"score_gpt":0.3696416401981001,"score_spread":0.2992317212929484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}