{"id":"W2083095889","doi":"10.1016/j.coi.2003.09.013","title":"Negative selection and autoimmunity","year":2003,"lang":"en","type":"review","venue":"Current Opinion in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Autoimmunity; Negative selection; Immunology; Clonal deletion; Mechanism (biology); Biology; Autoimmune disease; Self Tolerance; T-cell receptor; Genetics; T cell; Immune system; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000839542,0.00128297,0.001509586,0.0008058555,0.0003996994,0.001260043,0.001236436,0.001723455,0.003213634],"category_scores_gemma":[0.0004807759,0.0002543528,0.00028283,0.0006183393,0.001449013,0.001742723,0.001088109,0.00227803,0.00176244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005192381,"about_ca_system_score_gemma":0.0006144295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000214765,"about_ca_topic_score_gemma":0.000359443,"domain_scores_codex":[0.999761,0.00004750914,0.00002150805,0.000041821,0.00009822936,0.00003000908],"domain_scores_gemma":[0.9997899,0.00006720014,0.00002899637,0.00001542356,0.00005175643,0.00004675457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002556198,0.00009734085,0.0003437526,0.00331766,0.00007055004,0.0008725199,0.0001036942,0.0004011929,0.01606894,0.02877294,0.1245211,0.8251748],"study_design_scores_gemma":[0.00003923641,0.00007284366,0.0005783596,0.0005144189,0.00005303322,0.002255183,0.00004652365,0.0001875749,0.001769524,0.019275,0.9751913,0.00001706454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00117575,0.9736866,0.002087421,0.003963594,0.01039505,0.00001176023,0.00002043865,0.00005897681,0.008600393],"genre_scores_gemma":[0.01336189,0.9435821,0.001032787,0.005573041,0.01672516,0.00004434533,0.0000681868,0.00002177615,0.0195907],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003213634,"threshold_uncertainty_score":0.01075071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06790447084525796,"score_gpt":0.3419904232902533,"score_spread":0.2740859524449953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}