{"id":"W2083142768","doi":"10.1074/jbc.m205369200","title":"Mutational, Structural, and Kinetic Studies of the ATP-binding Site of Methanobacterium thermoautotrophicum Nicotinamide Mononucleotide Adenylyltransferase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Nicotinamide mononucleotide; Chemistry; Methanobacterium; Nicotinamide; Biochemistry; Binding site; NAD+ kinase; Stereochemistry; Enzyme; Nicotinamide adenine dinucleotide; Gene; Archaea","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003026365,0.0003372316,0.0002438052,0.0001326872,0.0001798352,0.000210231,0.0003413652,0.0002600029,0.0005072088],"category_scores_gemma":[0.0004896244,0.0001581938,0.0002555046,0.0002377579,0.0001935744,0.0001714157,0.0001479363,0.0004191967,0.0001885357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000609077,"about_ca_system_score_gemma":0.0003695127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004504583,"about_ca_topic_score_gemma":0.004539037,"domain_scores_codex":[0.9997851,0.00005379324,0.00002731592,0.00002296198,0.00008530256,0.00002548857],"domain_scores_gemma":[0.9997407,0.00007764438,0.00006290473,0.00002226433,0.00004959118,0.00004686038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003207752,0.0001154875,0.001428859,0.00006034612,0.00001243436,0.0001371595,0.00006787427,0.00145248,0.9943429,0.0002060194,0.00002539718,0.001830229],"study_design_scores_gemma":[0.00003786022,0.0003435071,0.01380508,0.00001753781,0.00004251542,0.0006603358,0.0001660628,0.0132201,0.9698319,0.0001274191,0.001722161,0.00002550714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984698,0.0002030578,0.0007780703,0.0000378445,0.000006747705,0.00001099708,0.0001272712,0.00000937213,0.0003568912],"genre_scores_gemma":[0.9974148,0.0001675297,0.001683488,0.00001557542,0.000002802549,0.000009073058,0.000298428,0.00001039513,0.0003976942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004504583,"threshold_uncertainty_score":0.00895673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0275705700891234,"score_gpt":0.2914575695923873,"score_spread":0.2638869995032639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}