{"id":"W2083142768","doi":"10.1074/jbc.m205369200","title":"Mutational, Structural, and Kinetic Studies of the ATP-binding Site of Methanobacterium thermoautotrophicum Nicotinamide Mononucleotide Adenylyltransferase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Nicotinamide mononucleotide; Chemistry; Methanobacterium; Nicotinamide; Biochemistry; Binding site; NAD+ kinase; Stereochemistry; Enzyme; Nicotinamide adenine dinucleotide; Gene; Archaea","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000287977,0.0001484264,0.0003029246,0.00001740247,0.00006277672,0.000007118233,0.0002232263,0.000171378,0.0000306546],"category_scores_gemma":[0.0007336389,0.00008441517,0.0002078396,0.00009888314,0.0004860011,0.000003946018,0.0001856201,0.0002161667,2.001194e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001203314,"about_ca_system_score_gemma":0.00005451111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002014448,"about_ca_topic_score_gemma":2.897167e-7,"domain_scores_codex":[0.9988688,0.0001151371,0.0004533848,0.0001790132,0.0002100331,0.0001736018],"domain_scores_gemma":[0.9991108,0.0000649237,0.0002929915,0.0001712425,0.0002781927,0.00008190241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001134565,0.00003761666,0.00429325,0.0001006577,0.0001375653,0.000005557259,0.00003970851,0.0000139705,0.9950825,0.00001854462,0.00003111159,0.000126066],"study_design_scores_gemma":[0.0004511699,0.0002240907,0.005189235,0.00005873622,0.00003551629,0.0001893293,0.0001011575,0.00000314818,0.9931173,0.0002298949,0.0003042448,0.0000962341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947904,0.004788654,0.0000376432,0.0001583872,0.00004342681,0.00007194016,0.00002388154,0.00000155867,0.00008408687],"genre_scores_gemma":[0.9984562,0.0009319733,0.0004376652,0.0000503112,0.00005586211,0.000001783504,0.000007508827,0.000008513744,0.00005015879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003856681,"threshold_uncertainty_score":0.3442351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0275705700891234,"score_gpt":0.2914575695923873,"score_spread":0.2638869995032639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}