{"id":"W2083169847","doi":"10.1158/1535-7163.targ-09-b98","title":"Abstract B98: Induction of metabolic and oxidative stresses by the novel inhibitor of NAD+ biosynthesis, GMX 1778, for specific killing of human glioblastomas","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"NAD+ kinase; Nicotinamide adenine dinucleotide; Biosynthesis; Cancer; Biochemistry; Nicotinamide; In vivo; Enzyme; Nicotinamide phosphoribosyltransferase; Cancer cell; Oxidative phosphorylation; In vitro; Biology; Cancer research; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001598674,0.0001774253,0.0002592364,0.00005432927,0.00005660323,0.00001117134,0.0002217229,0.0001695904,0.000006485697],"category_scores_gemma":[0.0000186455,0.0001389615,0.000137625,0.0001493858,0.0002867868,0.000005092824,0.00004894534,0.0001105618,8.464696e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007526855,"about_ca_system_score_gemma":0.00005433439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005161219,"about_ca_topic_score_gemma":0.000008616342,"domain_scores_codex":[0.9989105,0.00003712123,0.0003266969,0.0002842264,0.0002302777,0.0002111129],"domain_scores_gemma":[0.9991463,0.00002386898,0.000234219,0.0003060308,0.0002419458,0.00004762405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001446708,0.0001830145,0.00005743533,0.00006081978,0.0002133768,2.296125e-7,0.00007013063,0.00001298182,0.9831756,0.0003796381,0.00005639665,0.01564575],"study_design_scores_gemma":[0.000549697,0.0003757977,0.0005687641,0.00005331808,0.00007255167,0.000001545955,0.0001026667,0.000009434236,0.99037,0.0001631926,0.007592769,0.0001402505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703048,0.0256364,0.003208051,0.0002399443,0.00003784942,0.0003344581,0.0001771106,0.00000352101,0.00005787499],"genre_scores_gemma":[0.9968719,0.002379479,0.0004571351,0.0001177291,0.00006555537,0.00002108858,0.00004707527,0.00002218867,0.00001779453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02656717,"threshold_uncertainty_score":0.5666687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02997847592673606,"score_gpt":0.3086536899765374,"score_spread":0.2786752140498013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}