{"id":"W2083169847","doi":"10.1158/1535-7163.targ-09-b98","title":"Abstract B98: Induction of metabolic and oxidative stresses by the novel inhibitor of NAD+ biosynthesis, GMX 1778, for specific killing of human glioblastomas","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"NAD+ kinase; Nicotinamide adenine dinucleotide; Biosynthesis; Cancer; Biochemistry; Nicotinamide; In vivo; Enzyme; Nicotinamide phosphoribosyltransferase; Cancer cell; Oxidative phosphorylation; In vitro; Biology; Cancer research; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000693393,0.0003779302,0.0001797517,0.0002630968,0.0001878687,0.000144238,0.0002498285,0.000236964,0.002790502],"category_scores_gemma":[0.00005002942,0.000101026,0.0001330683,0.0001495746,0.0001158914,0.0001044467,0.0001267564,0.0003270519,0.0006837682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716452,"about_ca_system_score_gemma":0.0003432239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049643,"about_ca_topic_score_gemma":0.001359932,"domain_scores_codex":[0.9999633,0.000005126365,0.000002515775,0.000004466044,0.00001508145,0.000009448982],"domain_scores_gemma":[0.9999853,0.000001792857,0.000002469712,0.000001887295,0.000002810115,0.000005657759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006333924,0.0001701627,0.0001171414,0.00008085266,0.00000781929,0.000121138,0.00001097335,0.0002580145,0.9860874,0.0005688443,0.001321619,0.01062263],"study_design_scores_gemma":[0.0001047632,0.0008022534,0.0009878901,0.000006582267,0.00001263552,0.0002724762,0.000005401223,0.0006271081,0.9882442,0.00007081748,0.008862382,0.00000357971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725176,0.00532703,0.004897065,0.0007551673,0.0002223123,0.00038107,0.001963416,0.0004261189,0.01351014],"genre_scores_gemma":[0.975895,0.002891587,0.007019223,0.0001448744,0.00003515949,0.0001621684,0.002245676,0.00004493885,0.01156141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002790502,"threshold_uncertainty_score":0.00933516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02997847592673606,"score_gpt":0.3086536899765374,"score_spread":0.2786752140498013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}