{"id":"W2083172058","doi":"10.1016/j.bbamem.2005.01.009","title":"High zinc sensitivity and pore formation in an invertebrate P2X receptor","year":2005,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Killam Trusts","keywords":"Homomeric; PPADS; Suramin; Purinergic receptor; Receptor; Extracellular; Cell biology; Biology; Zinc; Biophysics; Protein subunit; Ligand-gated ion channel; Purinergic signalling; Ion channel; P2Y receptor; Biochemistry; Kinetics; Chemistry; Agonist; Adenosine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002206907,0.0003170078,0.0002802392,0.0001530765,0.0001069529,0.00008415245,0.000159735,0.0002436358,0.00001644319],"category_scores_gemma":[0.00002375593,0.000296505,0.00008074543,0.0002592024,0.0001455965,0.00007742455,0.0001326692,0.0001381222,0.00001792611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000212433,"about_ca_system_score_gemma":0.00004381551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036869,"about_ca_topic_score_gemma":0.0001197682,"domain_scores_codex":[0.9984279,0.0001831624,0.0003363703,0.0005372415,0.0001634071,0.0003518617],"domain_scores_gemma":[0.9992328,0.00002376226,0.0001584483,0.0003712979,0.00006937969,0.00014428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000149324,0.0001588655,0.00002576002,0.00004449572,0.00002806188,0.000005783599,0.0002401933,0.0000243511,0.9966723,0.00008029566,0.00168033,0.0008902928],"study_design_scores_gemma":[0.0007600138,0.0002369564,0.001494906,0.00003236214,0.00002157038,0.00003593598,0.0001025706,0.001093853,0.9938585,0.00003996115,0.001912117,0.0004113051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969972,0.0002500367,0.0000395538,0.002194912,0.00009172835,0.000218674,0.00008438498,0.00004510189,0.00007836376],"genre_scores_gemma":[0.9959472,0.0004008976,0.0007496807,0.0009044094,0.0006166154,0.00001600647,0.001223107,0.00003884188,0.0001032278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002813799,"threshold_uncertainty_score":0.9999487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101251656768576,"score_gpt":0.2429230318475898,"score_spread":0.2319105152799041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}