{"id":"W2083172058","doi":"10.1016/j.bbamem.2005.01.009","title":"High zinc sensitivity and pore formation in an invertebrate P2X receptor","year":2005,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Killam Trusts","keywords":"Homomeric; PPADS; Suramin; Purinergic receptor; Receptor; Extracellular; Cell biology; Biology; Zinc; Biophysics; Protein subunit; Ligand-gated ion channel; Purinergic signalling; Ion channel; P2Y receptor; Biochemistry; Kinetics; Chemistry; Agonist; Adenosine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365251,0.0001351167,0.000199014,0.0001633609,0.0002740813,0.0004375836,0.0003092454,0.0004941603,0.0008638787],"category_scores_gemma":[0.0002839502,0.0002136808,0.0001779267,0.00009659653,0.0003423276,0.0005626247,0.0004217067,0.0005616553,0.000263007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000346689,"about_ca_system_score_gemma":0.0001034001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005288576,"about_ca_topic_score_gemma":0.0007206199,"domain_scores_codex":[0.9998808,0.00001500866,0.0000117683,0.00002557041,0.00003694978,0.0000299075],"domain_scores_gemma":[0.9997544,0.00007656978,0.00006493418,0.00003860024,0.00002063379,0.00004492283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007681284,0.000004049488,0.0001320765,0.00001288932,0.00000189039,0.00007367467,0.00001235181,0.00002867693,0.9991674,0.000230016,0.00001131766,0.0002487455],"study_design_scores_gemma":[0.00001764872,0.00004517474,0.005980965,0.000003097189,0.000006737719,0.0006819176,0.0000257603,0.0009882781,0.9914983,0.0001914503,0.0005553821,0.000005338195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958625,0.0004729279,0.002745049,0.000114562,0.000008035423,0.000006627072,0.0001004037,0.00004855973,0.0006412441],"genre_scores_gemma":[0.9980907,0.0001569634,0.000888954,0.00002247871,0.000003114849,0.000004867513,0.00006728514,0.00001350485,0.0007520993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008638787,"threshold_uncertainty_score":0.002889991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101251656768576,"score_gpt":0.2429230318475898,"score_spread":0.2319105152799041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}