{"id":"W2083183766","doi":"10.1242/dev.00473","title":"Tbx5 is required for forelimb bud formation and continued outgrowth","year":2003,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Forelimb; Biology; Limb development; Limb bud; Haploinsufficiency; Context (archaeology); Apical ectodermal ridge; Anatomy; Hindlimb; Gene; Genetics; Mesoderm; Phenotype; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124112,0.00008571193,0.00007949963,0.00003419934,0.00009171966,0.00002567375,0.00004899863,0.00006929275,0.00001308173],"category_scores_gemma":[0.00007729106,0.00008204861,0.00002814844,0.00004163151,0.00002251275,0.000004731972,0.0000422208,0.00002808367,0.00001360331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001940695,"about_ca_system_score_gemma":0.00008173149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000119039,"about_ca_topic_score_gemma":0.00001735828,"domain_scores_codex":[0.9993417,0.00002032256,0.0001429724,0.0001849903,0.00009810609,0.0002118711],"domain_scores_gemma":[0.9996865,0.00001207889,0.0000252309,0.0001151182,0.00009449069,0.00006652045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004216626,0.0001436367,0.006633829,0.0003973257,0.0002156138,0.000005841626,0.002154246,9.853021e-7,0.7473609,0.001766331,0.02877424,0.2121253],"study_design_scores_gemma":[0.0005704194,0.00009622618,0.001427743,0.000006597942,0.000003048091,0.00000956569,0.0000486782,0.0000216467,0.5476013,0.00008065578,0.4500293,0.0001048522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988158,0.0005388485,0.006760254,0.0001143088,0.00006480429,0.0005408205,0.000009670716,0.000009899661,0.003803378],"genre_scores_gemma":[0.9907728,0.00004111436,0.005922134,0.0001914713,0.00002369734,0.0001088325,0.00008120765,0.00001317965,0.002845595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4212551,"threshold_uncertainty_score":0.3345845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215112176033346,"score_gpt":0.2811518382837067,"score_spread":0.2596406206803721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}