{"id":"W2083193004","doi":"10.1371/journal.pcbi.0020044","title":"Spatial Regulation and the Rate of Signal Transduction Activation","year":2006,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation","keywords":"Endocytosis; Signal transduction; Cell biology; Exocytosis; Cell surface receptor; Cell; Receptor; Cell membrane; Cytoplasm; Biology; Biophysics; Transduction (biophysics); Chemistry; Membrane; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009069843,0.00006454071,0.00008674166,0.00002547836,0.00005132266,0.000004739626,0.00003855335,0.00007384483,0.00002733621],"category_scores_gemma":[0.00001266538,0.0000449832,0.00003342665,0.00003767186,0.0001779775,0.000003273981,0.00001230812,0.00003455637,6.228406e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003286781,"about_ca_system_score_gemma":0.0000228527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007504658,"about_ca_topic_score_gemma":0.00001038845,"domain_scores_codex":[0.9995079,0.00009944019,0.0001509879,0.0001379319,0.00004073144,0.0000629908],"domain_scores_gemma":[0.9997257,0.00004317402,0.0000834493,0.00005485209,0.00008322523,0.00000958103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002531364,0.00002261193,0.001378513,0.000006559883,0.00001879499,3.27427e-8,0.00001597404,0.00193303,0.9895834,0.004963809,0.00003414047,0.001790026],"study_design_scores_gemma":[0.001347933,0.0001131772,0.05989804,0.000003856199,0.00003098827,0.000006464405,0.000007184129,0.002172168,0.9250827,0.01086633,0.0003950156,0.0000761015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726631,0.00002619353,0.02655733,0.0004158998,0.00005657478,0.0001420448,0.00001173636,0.000005316547,0.0001217931],"genre_scores_gemma":[0.998436,0.000003986243,0.0004977593,0.00007704936,0.0003283474,0.000009264478,0.0006083712,0.00000474539,0.0000344259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06450062,"threshold_uncertainty_score":0.1834362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007453261784325956,"score_gpt":0.2206949897930019,"score_spread":0.2132417280086759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}