{"id":"W2083193359","doi":"10.1042/bj20040373","title":"Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5)","year":2005,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Protein arginine methyltransferase 5; Jurkat cells; Methylation; Methyltransferase; Molecular biology; Arginine; Gene expression; Protein methylation; Biology; Regulation of gene expression; DNA methylation; Arginine deiminase; Gene; Biochemistry; T cell; Amino acid; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002231683,0.0004469902,0.0002459745,0.0001496291,0.0001801209,0.0004798252,0.0001879508,0.0004642174,0.001115281],"category_scores_gemma":[0.0001385481,0.0001295177,0.0003526098,0.0001168292,0.0003090123,0.000319523,0.000191781,0.0005145457,0.000382889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002650905,"about_ca_system_score_gemma":0.0001675139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002455286,"about_ca_topic_score_gemma":0.0003366675,"domain_scores_codex":[0.9997935,0.00004346548,0.00001775259,0.00006338754,0.00004102009,0.00004092365],"domain_scores_gemma":[0.9998759,0.00002465213,0.0000415114,0.00001123808,0.00001770692,0.0000289747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096333,0.0000106674,0.0002736099,0.00004157557,0.000003611492,0.00005094562,0.00001236674,0.00002877497,0.9981065,0.00006012096,0.00002316097,0.00127913],"study_design_scores_gemma":[0.00003312292,0.0003454837,0.01266154,0.00001378372,0.00002987983,0.000497379,0.00004256459,0.000876703,0.9813297,0.000149413,0.004013205,0.00000737882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9406723,0.03386696,0.0200652,0.0009877398,0.0001940904,0.00007890597,0.0006759569,0.0003161396,0.003142619],"genre_scores_gemma":[0.9868815,0.004374772,0.005772836,0.0002163843,0.00006626467,0.00004729413,0.0003977676,0.00002334295,0.002219803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115281,"threshold_uncertainty_score":0.003731012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008131054223317521,"score_gpt":0.2515373641801835,"score_spread":0.2434063099568659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}