{"id":"W2083232319","doi":"10.1126/science.1243990","title":"HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Université de Lausanne; National Science Foundation; National Institutes of Health; Simon Fraser University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Serine; Transferase; Biochemistry; Threonine; Glycosylation; Cysteine; Cleavage (geology); Active site; Glutamine; Chemistry; Asparagine; Acetylation; Cleave; Site-directed mutagenesis; Amino acid; Cell biology; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361724,0.0002774854,0.0001531988,0.0001272157,0.0001705064,0.000283751,0.0001574604,0.0002903169,0.001292876],"category_scores_gemma":[0.0001954267,0.0001208259,0.0002054871,0.0001244299,0.0001854314,0.000167208,0.0001360353,0.000399691,0.0006243501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005202011,"about_ca_system_score_gemma":0.0002283059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000968685,"about_ca_topic_score_gemma":0.001046775,"domain_scores_codex":[0.9998906,0.00001264505,0.000004471707,0.00002917772,0.00002881585,0.00003422532],"domain_scores_gemma":[0.9998924,0.0000176547,0.00003449342,0.00001197403,0.00001297225,0.00003056055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008793816,0.00001152059,0.0006354853,0.00001441439,0.000003716421,0.0001173046,0.00001313278,0.00003902861,0.9974599,0.0001437497,0.00005180579,0.001421878],"study_design_scores_gemma":[0.00001589717,0.0001514153,0.01251607,0.00000633748,0.000007580444,0.001245797,0.00003855586,0.0006779137,0.9793183,0.000110662,0.005906627,0.0000049076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948801,0.001128288,0.002731019,0.00007834562,0.00002313268,0.00001338353,0.0001919379,0.00003301877,0.0009207753],"genre_scores_gemma":[0.9931607,0.000532105,0.001914693,0.00005480586,0.00001350888,0.000009343775,0.00116518,0.00001105022,0.003138487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292876,"threshold_uncertainty_score":0.004325151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108177817300041,"score_gpt":0.2840566375738529,"score_spread":0.2732388558438488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}