{"id":"W2083232319","doi":"10.1126/science.1243990","title":"HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Université de Lausanne; National Science Foundation; National Institutes of Health; Simon Fraser University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Serine; Transferase; Biochemistry; Threonine; Glycosylation; Cysteine; Cleavage (geology); Active site; Glutamine; Chemistry; Asparagine; Acetylation; Cleave; Site-directed mutagenesis; Amino acid; Cell biology; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002997983,0.00004264686,0.00004246741,0.00005028912,0.0000569253,0.00002263563,0.0002755526,0.00002949588,0.0001270773],"category_scores_gemma":[0.00007601808,0.00002853633,0.00002427949,0.0003343648,0.0002917514,0.000009182551,0.00003571062,0.00005854517,0.0000417171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005890581,"about_ca_system_score_gemma":0.00008903658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001303741,"about_ca_topic_score_gemma":0.00005722283,"domain_scores_codex":[0.9993172,0.00003385095,0.00008056431,0.0001701067,0.0002373333,0.0001609477],"domain_scores_gemma":[0.9996147,0.000008136224,0.00001518967,0.000224445,0.000101359,0.00003620087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001341341,0.00002528131,0.001011955,0.000002876557,9.611587e-7,3.79178e-7,0.0005448588,0.00000474442,0.9922499,0.00004567436,0.0001906446,0.005909292],"study_design_scores_gemma":[0.0002020555,0.0001065905,0.07901678,0.000003563662,6.17e-7,0.000001753323,0.000329555,0.0002208719,0.9165945,0.0001170443,0.003359358,0.00004728914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959553,0.00003737906,0.0001200544,0.0007753865,0.00001615087,0.00022965,0.000006070128,0.000001362294,0.002858676],"genre_scores_gemma":[0.9992228,0.00002022523,0.00009667811,0.0003703121,0.00001360504,0.00002037082,0.000002894018,0.00000211782,0.000250962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07800483,"threshold_uncertainty_score":0.1391407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108177817300041,"score_gpt":0.2840566375738529,"score_spread":0.2732388558438488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}