{"id":"W2083236593","doi":"10.1016/j.cub.2009.02.011","title":"Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome","year":2009,"lang":"en","type":"article","venue":"Current Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"AIM2; Inflammasome; Biology; Innate immune system; Caspase 1; Secretion; Cell biology; Pyroptosis; DNA; Cytoplasm; Immunity; Programmed cell death; Mechanism (biology); Apoptosis; Genetics; Inflammation; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005660685,0.0005952839,0.0005285749,0.0004963006,0.0003994042,0.001386531,0.0003824915,0.001044664,0.002527471],"category_scores_gemma":[0.0005403483,0.0002187896,0.0003812886,0.0002772612,0.0007966404,0.002089085,0.0007804225,0.001318852,0.001179166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005870456,"about_ca_system_score_gemma":0.0003976098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001048519,"about_ca_topic_score_gemma":0.0001028758,"domain_scores_codex":[0.999691,0.00007168799,0.00002482667,0.0000736832,0.00008675084,0.00005211405],"domain_scores_gemma":[0.9997223,0.00004075615,0.00006525242,0.00003588676,0.00006130651,0.00007444126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008087507,0.000057272,0.001015901,0.0005022157,0.00002923633,0.0008502776,0.0001104097,0.0003919895,0.9556707,0.01713437,0.001713299,0.02171553],"study_design_scores_gemma":[0.0002184208,0.0007183706,0.009319331,0.000280465,0.0001060584,0.009525586,0.0005775298,0.004994314,0.8729399,0.0376869,0.06351381,0.0001192982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5935166,0.1911063,0.1400674,0.02360209,0.003852119,0.000106541,0.001376542,0.001576669,0.04479563],"genre_scores_gemma":[0.95618,0.01998636,0.01157462,0.001631823,0.0007801526,0.0000581136,0.0005520432,0.00005895821,0.009178044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002527471,"threshold_uncertainty_score":0.008455276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009339294852956474,"score_gpt":0.2606177346773944,"score_spread":0.2512784398244379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}