{"id":"W2083236593","doi":"10.1016/j.cub.2009.02.011","title":"Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome","year":2009,"lang":"en","type":"article","venue":"Current Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"AIM2; Inflammasome; Biology; Innate immune system; Caspase 1; Secretion; Cell biology; Pyroptosis; DNA; Cytoplasm; Immunity; Programmed cell death; Mechanism (biology); Apoptosis; Genetics; Inflammation; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179581,0.0002187198,0.0001768177,0.00004587549,0.000214275,0.00002587055,0.0003351541,0.0001840071,0.00001714127],"category_scores_gemma":[0.00008372613,0.000161327,0.0001173049,0.0001178548,0.0001922026,0.00000517234,0.000123643,0.0002618834,0.0000532482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001314677,"about_ca_system_score_gemma":0.00005360898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008746921,"about_ca_topic_score_gemma":0.000007915675,"domain_scores_codex":[0.9987856,0.0001670659,0.0002653434,0.0003010101,0.00005858919,0.0004223509],"domain_scores_gemma":[0.9992784,0.0000178327,0.0001084929,0.0004892404,0.0000617149,0.00004432693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005527556,0.0000401148,0.0006509646,0.000004422435,0.00003455355,6.480765e-7,0.00007318828,0.000003734282,0.8536559,0.0002912922,0.006775546,0.1384144],"study_design_scores_gemma":[0.0007215304,0.0003737847,0.001772672,0.00001345528,0.00002090985,0.00002641593,0.00009921059,0.0000459146,0.286283,0.0009608939,0.7093523,0.0003298896],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876751,0.008534057,0.0004108222,0.001057275,0.0006304569,0.0001872428,0.00001887257,0.00002699416,0.001459148],"genre_scores_gemma":[0.9966294,0.001447167,0.00002369191,0.0007973158,0.0002101269,0.000004849438,0.0006479246,0.00001427666,0.0002252037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7025768,"threshold_uncertainty_score":0.6578723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009339294852956474,"score_gpt":0.2606177346773944,"score_spread":0.2512784398244379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}