{"id":"W2083249633","doi":"10.1038/nbt.1602","title":"Rational design of cationic lipids for siRNA delivery","year":2010,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1779,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Arbutus Biopharma (Canada)","funders":"Alnylam Pharmaceuticals","keywords":"Cationic polymerization; In vivo; Gene silencing; Rational design; Nucleic acid; Small interfering RNA; Chemistry; Biochemistry; Lipid metabolism; Gene delivery; RNA; Cell biology; Biophysics; Pharmacology; Transfection; Biology; Gene; Biotechnology; Organic chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006471793,0.0007032905,0.0004333869,0.000380746,0.0004182995,0.0008627299,0.0006569828,0.0006813603,0.001228011],"category_scores_gemma":[0.0005993956,0.0004496376,0.0004080904,0.0002939611,0.0004759555,0.0007003042,0.0005916472,0.001051894,0.0008075678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001348848,"about_ca_system_score_gemma":0.00109544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007556771,"about_ca_topic_score_gemma":0.001664569,"domain_scores_codex":[0.9997765,0.000044136,0.00002593513,0.00003356402,0.00006928955,0.00005049515],"domain_scores_gemma":[0.999869,0.00003247876,0.00003531246,0.000007324637,0.00003183207,0.00002404436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004384471,0.0001070123,0.0001684454,0.0004592479,0.00002641,0.0004810834,0.0001051568,0.009342238,0.965176,0.01033016,0.0003659052,0.01299983],"study_design_scores_gemma":[0.0002132482,0.0004188977,0.00009409843,0.00003887847,0.00003052573,0.0002296467,0.00004722906,0.01114088,0.9737765,0.00143078,0.01254454,0.00003475475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7628218,0.008408341,0.2124366,0.001763673,0.0002574726,0.001386575,0.0005517955,0.0007646939,0.011609],"genre_scores_gemma":[0.8686972,0.00645299,0.1173723,0.0003180428,0.00001842617,0.000577514,0.000350557,0.0001115519,0.006101378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001348848,"threshold_uncertainty_score":0.009786665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007560205958995733,"score_gpt":0.2512367102096107,"score_spread":0.243676504250615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}