{"id":"W2083287741","doi":"10.1016/j.chom.2011.03.008","title":"Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection","year":2011,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":174,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of British Columbia; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; PI3K/AKT/mTOR pathway; Leishmania; Cell biology; Leishmania major; mTORC1; Parasite hosting; Kinase; Mechanistic target of rapamycin; EIF4E; Translation (biology); Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636201,0.0002777761,0.0003091057,0.0003400916,0.0003452894,0.000890704,0.0002301731,0.000266668,0.002251378],"category_scores_gemma":[0.0002954133,0.0002125059,0.0002960895,0.0001417052,0.0003683004,0.0003421424,0.0002845307,0.0006846455,0.0008283225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000638615,"about_ca_system_score_gemma":0.0003530589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005297783,"about_ca_topic_score_gemma":0.0009216663,"domain_scores_codex":[0.9997336,0.0000530846,0.00003189409,0.00004240953,0.00005764786,0.00008123373],"domain_scores_gemma":[0.9997994,0.00002932021,0.00006294827,0.00001899192,0.00003863491,0.00005068969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000505246,0.00003884434,0.0005047054,0.00006328541,0.000009726953,0.0001260785,0.00001405056,0.00003812486,0.996558,0.0004985977,0.0001663043,0.001476915],"study_design_scores_gemma":[0.00003229031,0.0002805395,0.02057442,0.00001478035,0.00002210696,0.0006827852,0.00008356808,0.0008986433,0.9739466,0.0001673702,0.003287751,0.000009118469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869794,0.005073065,0.001803524,0.0004193387,0.00006315028,0.00003118233,0.0005312568,0.0001226094,0.004976372],"genre_scores_gemma":[0.9947219,0.0007639218,0.0009466069,0.0000741164,0.00002087342,0.00001816446,0.0006902923,0.00002655176,0.002737674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002251378,"threshold_uncertainty_score":0.007531643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07839283683690268,"score_gpt":0.325196601331083,"score_spread":0.2468037644941803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}