{"id":"W2083287741","doi":"10.1016/j.chom.2011.03.008","title":"Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection","year":2011,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":174,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of British Columbia; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; PI3K/AKT/mTOR pathway; Leishmania; Cell biology; Leishmania major; mTORC1; Parasite hosting; Kinase; Mechanistic target of rapamycin; EIF4E; Translation (biology); Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003580264,0.0002020452,0.0004344808,0.000100053,0.000151322,0.00001695308,0.00007547579,0.0001519072,0.0000870101],"category_scores_gemma":[0.00008082586,0.0001792528,0.0001359983,0.0001737501,0.0001895029,0.0002662885,0.00006307186,0.0001572351,0.00001946394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004565735,"about_ca_system_score_gemma":0.00004289366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006348371,"about_ca_topic_score_gemma":0.0000809943,"domain_scores_codex":[0.9985564,0.00007322826,0.000398066,0.0004374151,0.0002148608,0.0003200181],"domain_scores_gemma":[0.9990215,0.0001172369,0.0001773988,0.0003756602,0.0002205741,0.00008768112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001026748,0.0003012898,0.05703815,0.0007487322,0.00009058174,0.000007204943,0.006579588,9.610855e-8,0.9262366,0.0000468635,0.005012054,0.002912098],"study_design_scores_gemma":[0.002474872,0.0007581624,0.2322011,0.0001970774,0.0001367184,0.0000106392,0.0003239754,0.0000256235,0.7505718,0.00007221632,0.0130548,0.0001729552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806818,0.001946101,0.001819589,0.0003371881,0.000221983,0.001245895,0.00005365806,0.00006495485,0.01362884],"genre_scores_gemma":[0.9928664,0.002145095,0.003637064,0.00009664067,0.0001179996,0.00004313037,0.00003523394,0.00004703542,0.001011417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1756648,"threshold_uncertainty_score":0.7309718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07839283683690268,"score_gpt":0.325196601331083,"score_spread":0.2468037644941803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}